Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

Background: Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and …

BACKGROUND: Smooth muscle cell (SMC) phenotypic switching has been increasingly
detected in aortic aneurysm and dissection (AAD) tissues. However, the diverse SMC …

Background: The development of thoracic aortic dissection (TAD) is closely related to
extracellular matrix degradation and vascular smooth muscle cell (VSMC) transformation …

Vascular smooth muscle cells (SMC) play a critical role in controlling blood pressure and
blood distribution, as well as maintaining the structural integrity of the blood vessel. SMC …

Objective The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to
vessel growth and remodeling, but also contributes to cardiovascular pathologies. New …

Aims Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective
pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied …

The aortic wall is composed of highly dynamic cell populations and extracellular matrix. In
response to changes in the biomechanical environment, aortic cells and extracellular matrix …