This nontechnical review is focused upon educating the reader on optic nerve head
biomechanics in both aging and disease along two main themes: what is known about how …

Biomechanics is the study of the relationship between forces and function in living
organisms and is thought to play a critical role in a significant number of ophthalmic …

Purpose: To determine whether aging modifies the effect of intraocular pressure (IOP) on
progressive glaucomatous retinal nerve fiber layer (RNFL) thinning over time. Methods: This …

Common risk factors for many ocular pathologies involve non-pathologic, age-related
damage to the optic nerve. Understanding the mechanisms of age-related changes can …

Age and intraocular pressure (IOP) are the two most important risk factors for the
development and progression of open-angle glaucoma. While IOP is commonly considered …

Mechanical strain due to increased pressure or swelling activates inflammatory responses in
many neural systems. As cytokines and chemokine messengers lead to both pro …

Retinal diseases such as age-related macular degeneration (AMD), retinopathy of
prematurity (ROP), and diabetic retinopathy (DR) are the leading causes of visual …

Introduction Glaucoma is a complex, multifactorial neurodegenerative disease, which can
lead to blindness if left untreated. It seems that, among others, immune processes, elevated …

Purpose To study the detailed cellular and molecular changes in the mouse sclera
subjected to experimental glaucoma. Methods Three strains of mice underwent …

Introduction Age-related diseases such as glaucoma, a leading cause of blindness, are
having an upward trend due to an aging society. In glaucoma, some patients display altered …