Ageing, oxidative stress and cancer: paradigms in parallax
CC Benz, C Yau - Nature Reviews Cancer, 2008 - nature.com
Two paradigms central to geroscience research are that aging is associated with increased
oxidative stress and increased cancer risk. Therefore, it could be deduced that cancers …
oxidative stress and increased cancer risk. Therefore, it could be deduced that cancers …
Potential therapeutic application of estrogen in gender disparity of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
C Lee, J Kim, Y Jung - Cells, 2019 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) caused by fat accumulation in the liver is globally
the most common cause of chronic liver disease. Simple steatosis can progress to …
the most common cause of chronic liver disease. Simple steatosis can progress to …
[HTML][HTML] The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites
Mechanistic roles for many lncRNAs are poorly understood, in part because their direct
interactions with genomic loci and proteins are difficult to assess. Using a method to purify …
interactions with genomic loci and proteins are difficult to assess. Using a method to purify …
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer
The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that
drives prostate cancer progression. Some prostate cancers escape androgen dependence …
drives prostate cancer progression. Some prostate cancers escape androgen dependence …
[HTML][HTML] A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells
We report the immediate effects of estrogen signaling on the transcriptome of breast cancer
cells using global run-on and sequencing (GRO-seq). The data were analyzed using a new …
cells using global run-on and sequencing (GRO-seq). The data were analyzed using a new …
YAP inhibits ERα and ER+ breast cancer growth by disrupting a TEAD-ERα signaling axis
Hippo signaling restricts tissue growth by inhibiting the transcriptional effector YAP. Here we
uncover a role of Hippo signaling and a tumor suppressor function of YAP in estrogen …
uncover a role of Hippo signaling and a tumor suppressor function of YAP in estrogen …
Whole-genome cartography of estrogen receptor α binding sites
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy,
we mapped estrogen receptor α (ERα) binding sites in MCF-7 breast cancer cells. We …
we mapped estrogen receptor α (ERα) binding sites in MCF-7 breast cancer cells. We …
Location analysis of estrogen receptor α target promoters reveals that FOXA1 defines a domain of the estrogen response
J Laganière, G Deblois, C Lefebvre… - Proceedings of the …, 2005 - National Acad Sciences
Nuclear receptors can activate diverse biological pathways within a target cell in response to
their cognate ligands, but how this compartmentalization is achieved at the level of gene …
their cognate ligands, but how this compartmentalization is achieved at the level of gene …
Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis
N Mohammadi Ghahhari, MK Sznurkowska… - Nature …, 2022 - nature.com
The epithelial to mesenchymal transition (EMT) has been proposed to contribute to the
metastatic spread of breast cancer cells. EMT-promoting transcription factors determine a …
metastatic spread of breast cancer cells. EMT-promoting transcription factors determine a …
SAR439859, a novel selective estrogen receptor degrader (SERD), demonstrates effective and broad antitumor activity in wild-type and mutant ER-positive breast …
M Shomali, J Cheng, F Sun, M Koundinya, Z Guo… - Molecular cancer …, 2021 - AACR
Primary treatment for estrogen receptor-positive (ER+) breast cancer is endocrine therapy.
However, substantial evidence indicates a continued role for ER signaling in tumor …
However, substantial evidence indicates a continued role for ER signaling in tumor …