Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …

Ubiquitination is the major criteria for the recognition of a substrate-protein by the 26S
proteasome. Additionally, a disordered segment on the substrate—either intrinsic or induced …

Patients with the heritable cancer disease, Lynch syndrome, carry germline variants in the
MLH1, MSH2, MSH6 and PMS2 genes, encoding the central components of the DNA …

Chaperone-mediated autophagy (CMA) and endosomal microautophagy (eMI) are
pathways for selective degradation of cytosolic proteins in lysosomes and late endosomes …

Parkinson's disease (PD) is a common and incurable neurodegenerative disorder that
arises from the loss of dopaminergic neurons in the substantia nigra and is mainly …

The expression of correctly folded and functional heterologous proteins is important in many
biotechnological production processes, whether it is enzymes, biopharmaceuticals or …

Small ubiquitin-related modifiers (SUMOs) function as post-translational protein
modifications and regulate nearly every aspect of cellular function. While a single ubiquitin …

The eukaryotic proteome undergoes constant surveillance by quality control systems that
either sequester, refold, or eliminate aberrant proteins by ubiquitin-dependent mechanisms …

Protein quality control (PQC) degrons are short protein segments that target misfolded
proteins for proteasomal degradation, and thus protect cells against the accumulation of …

Protein homeostasis is an essential component of proper cellular function; however,
sustaining protein health is a challenging task, especially during the aerobic lifestyle …