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Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
Genetics of substance use disorders: a review
Substance use disorders (SUDs) are prevalent and result in an array of negative
consequences. They are influenced by genetic factors (h2=~ 50%). Recent years have …
consequences. They are influenced by genetic factors (h2=~ 50%). Recent years have …
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits
Problematic alcohol use (PAU) is a leading cause of death and disability worldwide.
Although genome-wide association studies have identified PAU risk genes, the genetic …
Although genome-wide association studies have identified PAU risk genes, the genetic …
Reproducible genetic risk loci for anxiety: results from∼ 200,000 participants in the Million Veteran Program
Objective: Anxiety disorders are common and often disabling. The goal of this study was to
examine the genetic architecture of anxiety disorders and anxiety symptoms, which are also …
examine the genetic architecture of anxiety disorders and anxiety symptoms, which are also …
Genetics of substance use disorders in the era of big data
Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals
Abstract Individuals with South Asian ancestry have a higher risk of heart disease than other
groups but have been largely excluded from genetic research. Using data from 22,000 …
groups but have been largely excluded from genetic research. Using data from 22,000 …
The genetically informed neurobiology of addiction (GINA) model
Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …
neurobiological theory proposes that substance-induced changes in neural circuitry promote …
Whole genome sequence analysis of the plasma proteome in black adults provides novel insights into cardiovascular disease
Background: Plasma proteins are critical mediators of cardiovascular processes and are the
targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma …
targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma …
Item-level genome-wide association study of the alcohol use disorders identification test in three population-based cohorts
Objective: Genome-wide association studies (GWASs) of the Alcohol Use Disorders
Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated …
Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated …