The role of cigarette smoke-induced epigenetic alterations in inflammation

D Zong, X Liu, J Li, R Ouyang, P Chen - Epigenetics & Chromatin, 2019 - Springer
Background Exposure to cigarette smoke (CS) is a major threat to human health worldwide.
It is well established that smoking increases the risk of respiratory diseases, cardiovascular …

DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies

X Gao, M Jia, Y Zhang, LP Breitling, H Brenner - Clinical epigenetics, 2015 - Springer
Active smoking is a major preventable public health problem and an established critical
factor for epigenetic modification. In this systematic review, we identified 17 studies …

DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis

BR Joubert, JF Felix, P Yousefi, KM Bakulski… - The American Journal of …, 2016 - cell.com
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array

G Mansell, TJ Gorrie-Stone, Y Bao, M Kumari… - BMC genomics, 2019 - Springer
Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …

Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study

S Ambatipudi, C Cuenin, H Hernandez-Vargas… - …, 2016 - Taylor & Francis
Aim: Epigenetic changes may occur in response to environmental stressors, and an altered
epigenome pattern may represent a stable signature of environmental exposure. Materials & …

DNA methylation-based age prediction using massively parallel sequencing data and multiple machine learning models

A Aliferi, D Ballard, MD Gallidabino, H Thurtle… - Forensic Science …, 2018 - Elsevier
The field of DNA intelligence focuses on retrieving information from DNA evidence that can
help narrow down large groups of suspects or define target groups of interest. With recent …

Epigenetic associations of type 2 diabetes and BMI in an Arab population

WA Al Muftah, M Al-Shafai, SB Zaghlool, A Visconti… - Clinical …, 2016 - Springer
Background The prevalence of type 2 diabetes (T2D) and obesity has dramatically
increased within a few generations, reaching epidemic levels. In addition to genetic risk …

Autosomal sex-associated co-methylated regions predict biological sex from DNA methylation

E Gatev, AM Inkster, GL Negri, C Konwar… - Nucleic Acids …, 2021 - academic.oup.com
Sex is a modulator of health that has been historically overlooked in biomedical research.
Recognizing this knowledge gap, funding agencies now mandate the inclusion of sex as a …

A systematic review of smoking-related epigenetic alterations

G Kaur, R Begum, S Thota, S Batra - Archives of Toxicology, 2019 - Springer
The aim of this study is to provide a systematic review of the known epigenetic alterations
caused by cigarette smoke; establish an evidence-based perspective of their clinical value …

Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites

SM Tajuddin, DG Hernandez, BH Chen… - Clinical …, 2019 - Springer
Abstract Background African Americans (AAs) experience premature chronic health
outcomes and longevity disparities consistent with an accelerated aging phenotype. DNA …