The currently available arsenal of anticancer modalities includes many DNA damaging
agents that can kill malignant cells. However, efficient DNA repair mechanisms protect both …

Mitotic catastrophe (MC) has long been considered as a mode of cell death that results from
premature or inappropriate entry of cells into mitosis and can be caused by chemical or …

This book focuses on heat shock response-an active yet transient reprogramming of cellular
activities to the needs of a stress protection mechanism designed to minimize heat damage …

Many cancer therapies cause DNA damage to effectively kill proliferating tumor cells;
however, a major limitation of current therapies is the emergence of resistant tumors …

Radiotherapy is used to treat approximately 50% of all cancer patients, with varying success.
Radiation therapy has become an integral part of modern treatment strategies for many …

Radiosensitizers are compounds or nanostructures, which can improve the efficiency of
ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells …

Mitotic death is a delayed response of p53 mutant tumours that are resistant to genotoxic
damage. Questions surround why this response is so delayed and how its mechanisms …

The cell cycle has the capacity to safeguard the cell's DNA from damage. Thus, cell cycle
arrest can allow tumor cells to investigate their own DNA repair processes. Cancer cells …

The nuclear matrix organizes nuclear DNA into operational domains in which DNA is
undergoing replication, transcription or is inactive. The proteins of the nuclear matrix are …

Background We have demonstrated that in some human cancer cells both chronic mild heat
and ionizing radiation exposures induce a transient block in S and G2 phases of the cell …