Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …

Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report
astrocyte molecular profiles, diversity, and morphology across the mouse central nervous …

There is increasing appreciation that non-neuronal cells contribute to the initiation,
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …

The circadian clock protein BMAL1 modulates glial activation and amyloid-beta deposition
in mice. However, the effects of BMAL1 on other aspects of neurodegenerative pathology …

Astrocytes are one of the brain's major cell types and are responsible for maintaining
neuronal homeostasis via regulating the extracellular environment, providing metabolic …

Astrocytes play a role in healthy cognitive function and Alzheimer's disease (AD). The
transcriptional factor nuclear factor-κB (NF-κB) drives astrocyte diversity, but the …

Background and Purpose Astrocytic nuclear factor erythroid‐derived 2‐related factor 2 (Nrf2)
is a potential therapeutic target of ischaemic preconditioning (IPC). Icariside II (ICS II) is a …

Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

Neuroinflammation is a common feature of neurodegenerative disorders such as
Alzheimer's disease (AD). Neuroinflammation is induced by dysregulated glial activation …