Neuroblastoma, the most common extracranial solid tumor in children, is derived from neural
crest cells. Nearly half of patients present with metastatic disease and have a 5-year event …

Criteria for evaluation of disease extent by 123I-metaiodobenzylguanidine scans in
neuroblastoma: a report for the International Neuroblastoma Risk Group (INRG) Task Force …

'See what you treat and treat what you see, at a molecular level', could be the motto of
theranostics. The concept implies diagnosis (imaging) and treatment of cells (usually …

Metaiodobenzylguanidine (MIBG) is structurally similar to the neurotransmitter
norepinephrine and specifically targets neuroendocrine cells including some …

As an analogue of adrenergic neurotransmitter norepinephrine (NE),
metaiodobenzylguanidine (MIBG) demonstrates high uptake both in normal sympathetically …

Neuroblastoma is unique amongst common pediatric cancers for its expression of the
norepinephrine transporter (NET), enabling tumor‐selective imaging and therapy with …

Neuroblastoma is the most common extracranial tumor of childhood, with about 650 new
cases each year in the United States. The clinical course of neuroblastoma is variable and …

Cancer cells reprogram their gene expression to promote growth, survival, proliferation, and
invasiveness. The unique expression of certain uptake transporters in cancers and their …

INTRODUCTION: Neuroblastoma is the most common pediatric extracranial solid cancer.
This tumor is characterized by metaiodobenzylguanidine (MIBG) avidity in 90% of cases …

Abstract Purpose Iodine-131-m-iodobenzylguanidine ([131 I] mIBG)-targeted radionuclide
therapy (TRT) is a standard treatment for recurrent or refractory neuroblastoma with …