The cortex is a thin, crosslinked actin network lying immediately beneath the plasma
membrane of animal cells. Myosin motors exert contractile forces in the meshwork. Because …

Septins belong to a family of proteins that is highly conserved in eukaryotes and is
increasingly recognized as a novel component of the cytoskeleton. All septins are GTP …

Septins are an integral component of the cytoskeleton, assembling into higher-order
oligomers and filamentous polymers that associate with actin filaments, microtubules and …

Many cell phenomena that involve shape changes are affected by the intrinsic deformability
of the plasma membrane (PM). Far from being a passive participant, the PM is now known to …

The morphological term 'amoeboid'migration subsumes a number of rather distinct
biophysical modes of cellular locomotion that range from blebbing motility to entirely actin …

The shuttling of leukocytes between the bloodstream and interstitial tissues involves different
locomotion strategies that are governed by locally presented soluble and cell-bound signals …

The anti-tumor effects of chemotherapy and radiation are thought to be mediated by
triggering G1/S or G2/M cell cycle checkpoints, while spindle poisons, such as paclitaxel …

Cells are active materials; they can change shape using internal energy to build contractile
networks of actin filaments and myosin motors. Contractility of the actomyosin cortex is tightly …

Animal cell cytokinesis requires a contractile ring of crosslinked actin filaments and myosin
motors. How contractile rings form and are stabilized in dividing cells remains unclear. We …

The planar cell polarity (PCP) signaling pathway governs collective cell movements during
vertebrate embryogenesis, and certain PCP proteins are also implicated in the assembly of …