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HIV and HLA class I: an evolving relationship
Successful vaccine development for infectious diseases has largely been achieved in
settings where natural immunity to the pathogen results in clearance in at least some …
settings where natural immunity to the pathogen results in clearance in at least some …
HIV control: Is getting there the same as staying there?
In this brief review and perspective, we address the question of whether the immune
responses that bring about immune control of acute HIV infection are the same as, or distinct …
responses that bring about immune control of acute HIV infection are the same as, or distinct …
Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control
Virus-specific CD8+ T cells probably mediate control over HIV replication in rare individuals,
termed long-term nonprogressors (LTNPs) or elite controllers. Despite extensive …
termed long-term nonprogressors (LTNPs) or elite controllers. Despite extensive …
Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy
SA Migueles, KA Weeks, E Nou, AM Berkley… - Journal of …, 2009 - journals.asm.org
Identifying the functions of human immunodeficiency virus (HIV)-specific CD8+ T cells that
are not merely modulated by the level of virus but clearly distinguish patients with immune …
are not merely modulated by the level of virus but clearly distinguish patients with immune …
Protective HLA Class I Alleles That Restrict Acute-Phase CD8+ T-Cell Responses Are Associated with Viral Escape Mutations Located in Highly Conserved Regions …
The control of human immunodeficiency virus type 1 (HIV-1) associated with particular HLA
class I alleles suggests that some CD8+ T-cell responses may be more effective than others …
class I alleles suggests that some CD8+ T-cell responses may be more effective than others …
Th17 cells and regulatory T cells in elite control over HIV and SIV
DJ Hartigan-O'Connor, LA Hirao… - Current Opinion in …, 2011 - journals.lww.com
Interactions between Th17 cells, T-reg, and cells of the innate immune system influence the
course of HIV and SIV infection from its earliest stages, even before the appearance of …
course of HIV and SIV infection from its earliest stages, even before the appearance of …
TRIM5α modulates immunodeficiency virus control in rhesus monkeys
The cytoplasmic TRIM5α proteins of certain mammalian lineages efficiently recognize the
incoming capsids of particular retroviruses and potently restrict infection in a species-specific …
incoming capsids of particular retroviruses and potently restrict infection in a species-specific …
CD8+ T cells in preventing HIV infection and disease
The complex interplay between the host immune response and HIV has been the subject of
intense research over the last 25 years. HIV and simian immunodeficiency virus (SIV) CD8+ …
intense research over the last 25 years. HIV and simian immunodeficiency virus (SIV) CD8+ …
Specific CD8+ T Cell Responses Correlate with Control of Simian Immunodeficiency Virus Replication in Mauritian Cynomolgus Macaques
Specific major histocompatibility complex (MHC) class I alleles are associated with an
increased frequency of spontaneous control of human and simian immunodeficiency viruses …
increased frequency of spontaneous control of human and simian immunodeficiency viruses …
Increased immunogenicity of HIV-1 p24 and gp120 following immunization with gp120/p24 fusion protein vaccine expressing α-gal epitopes
UM Abdel-Motal, S Wang, A Awad, S Lu… - Vaccine, 2010 - Elsevier
Develo** an effective HIV-1 vaccine will require strategies to enhance antigen
presentation to the immune system. In a previous study we demonstrated a marked increase …
presentation to the immune system. In a previous study we demonstrated a marked increase …