The deposition of amyloid in brain tissue in the context of neurodegenerative diseases
involves the formation of intermediate species—termed oligomers—of lower molecular mass …

Beyond the well-explored proposition of protein aggregation or amyloidosis as the central
event in amyloidogenic diseases like Alzheimer's Disease (AD), and Type 2 Diabetes …

Histone deacetylase 6 (HDAC6) plays a key role in a variety of neurological disorders, which
makes it attractive drug target for the treatment of Alzheimer's disease, Parkinson's disease …

Zinc-induced neurotoxicity has been shown to play a role in neuronal damage and death
associated with traumatic brain injury, stroke, seizures, and neurodegenerative diseases …

Amyloids are protein aggregates bearing a highly ordered cross β structural motif, which
may be functional but are mostly pathogenic. Their formation, deposition in tissues and …

Clinical studies have identified Type 2 diabetes (T2D) as a risk factor of Alzheimer's disease
(AD). One of the potential mechanisms that link T2D and AD is the loss of cells associated …

The classical force field, which is compatible with the Amber force field 99SB, has been
obtained for the interaction of Cu (II) with monomer and dimers of amyloid-β peptides using …

Casein phosphopeptides (CPPs) as premium additives in functional foods can facilitate the
transport and adsorption of calcium. The atomic resolution decipherment of calcium–CPP …

The A2V mutation was reported to protect from Alzheimer's disease in its heterozygous form
and cause an early Alzheimer's disease type dementia in its homozygous form. Experiments …

Amyloid beta (Aβ) oligomerization is associated with the origin and progression of
Alzheimer's disease (AD). While the A2V mutation enhances aggregation kinetics and …