The prediction of transcription factor (TF) activities from the gene expression of their targets
(ie, TF regulon) is becoming a widely used approach to characterize the functional status of …

There are only a few platforms that integrate multiple omics data types, bioinformatics tools,
and interfaces for integrative analyses and visualization that do not require programming …

Phosphoproteomics and proteomics experiments capture a global snapshot of the cellular
signaling network, but these methods do not directly measure kinase state. Kinase …

Lung cancers are the leading cause of cancer-related mortality worldwide, and the majority
of lung cancers are non–small cell lung carcinoma (NSCLC). Overexpressed or activated …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
formation of amyloid plaques implicated in neuronal death. Genetics, age, and sex are the …

Creating in vitro models of diseases of the pancreatic ductal compartment requires a
comprehensive understanding of the developmental trajectories of pancreas-specific cell …

Identifying the molecular systems and proteins that modify the progression of Alzheimer's
disease and related dementias (ADRD) is central to drug target selection. However …

Multiple types of molecular data for the same set of clinical samples are increasingly
available and may be analyzed jointly in an integrative analysis to maximize comprehensive …

IgA nephropathy (IgAN) is characterized by glomerular deposition of immune complexes
(ICs) consisting of IgA1 with O-glycans deficient in galactose (Gd-IgA1) and Gd-IgA1-specific …

The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma
stem cells (GSC), which are thought to underlie tumor growth, treatment resistance, and …