The Haematopoietically-expressed homeobox transcription factor: roles in development, physiology and disease
The Haematopoietically expressed homeobox transcription factor (Hhex) is a transcriptional
repressor that is of fundamental importance across species, as evident by its evolutionary …
repressor that is of fundamental importance across species, as evident by its evolutionary …
CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis
Dysregulation of Hippo pathway leads to hyperactivation of YAP-TEAD transcriptional
complex in various cancers, including colorectal cancer (CRC). In this study, we observed …
complex in various cancers, including colorectal cancer (CRC). In this study, we observed …
CK2 and the Hallmarks of Cancer
MB Firnau, A Brieger - Biomedicines, 2022 - mdpi.com
Cancer is a leading cause of death worldwide. Casein kinase 2 (CK2) is commonly
dysregulated in cancer, impacting diverse molecular pathways. CK2 is a highly conserved …
dysregulated in cancer, impacting diverse molecular pathways. CK2 is a highly conserved …
Phosphorylation of GntR reduces Streptococcus suis oxidative stress resistance and virulence by inhibiting NADH oxidase transcription
K Niu, Y Meng, M Liu, Z Ma, H Lin, H Zhou… - PLoS …, 2023 - journals.plos.org
GntR transcription factor of Streptococcus suis serotype 2 (SS2) is a potential substrate
protein of STK, but the regulation mechanisms of GntR phosphorylation are still unclear. This …
protein of STK, but the regulation mechanisms of GntR phosphorylation are still unclear. This …
Blood platelets stimulate cancer extravasation through TGFβ-mediated downregulation of PRH/HHEX
Cancer cells go through a process known as epithelial–mesenchymal transition (EMT)
during which they acquire the ability to migrate and invade extracellular matrix. Some cells …
during which they acquire the ability to migrate and invade extracellular matrix. Some cells …
Protein kinase CK2α subunit over-expression correlates with metastatic risk in breast carcinomas: quantitative immunohistochemistry in tissue microarrays
S Giusiano, C Cochet, O Filhol… - European journal of …, 2011 - Elsevier
BACKGROUND: CK2α is a signalling molecule that participates in major events in solid
tumour progression. The aim of this study was to evaluate the prognostic significance of the …
tumour progression. The aim of this study was to evaluate the prognostic significance of the …
Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion
K Gaston, MA Tsitsilianos, K Wadey, PS Jayaraman - Cell & bioscience, 2016 - Springer
The proline rich homeodomain protein (PRH), also known as haematopoietically expressed
homeobox (HHEX), is an essential transcription factor in embryonic development and in the …
homeobox (HHEX), is an essential transcription factor in embryonic development and in the …
Proline-Rich Homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth
RM Kershaw, D Roberts, J Wragg, AM Shaaban… - Oncogenesis, 2017 - nature.com
Breast tumours progress from hyperplasia to ductal carcinoma in situ (DCIS) and invasive
breast carcinoma (IBC). PRH/HHEX (proline-rich homeodomain/haematopoietically …
breast carcinoma (IBC). PRH/HHEX (proline-rich homeodomain/haematopoietically …
Inhibition of intimal thickening by PRH (proline-rich homeodomain) in mice
LM Reolizo, H Williams, K Wadey… - … and Vascular Biology, 2023 - Am Heart Assoc
Background: Late vein graft failure is caused by intimal thickening resulting from endothelial
cell (EC) damage and inflammation which promotes vascular smooth muscle cell (VSMC) …
cell (EC) damage and inflammation which promotes vascular smooth muscle cell (VSMC) …
CK2 abrogates the inhibitory effects of PRH/HHEX on prostate cancer cell migration and invasion and acts through PRH to control cell proliferation
PRH/HHEX (proline-rich homeodomain protein/haematopoietically expressed homeobox
protein) is a transcription factor that controls cell proliferation, cell differentiation and cell …
protein) is a transcription factor that controls cell proliferation, cell differentiation and cell …