The power of weak, transient interactions across biology: A paradigm of emergent behavior
A growing list of diverse biological systems and their equally diverse functionalities provides
realizations of a paradigm of emergent behavior. In each of these biological systems …
realizations of a paradigm of emergent behavior. In each of these biological systems …
On a model-based approach to improve intranasal spray targeting for respiratory viral infections
MMH Akash, Y Lao, PA Balivada, P Ato… - Frontiers in Drug …, 2023 - frontiersin.org
The nasopharynx, at the back of the nose, constitutes the dominant initial viral infection
trigger zone along the upper respiratory tract. However, as per the standard recommended …
trigger zone along the upper respiratory tract. However, as per the standard recommended …
Mucus from human bronchial epithelial cultures: rheology and adhesion across length scales
Mucus is a viscoelastic aqueous fluid that participates in the protective barrier of many
mammals' epithelia. In the airways, together with cilia beating, mucus rheological properties …
mammals' epithelia. In the airways, together with cilia beating, mucus rheological properties …
Coarse-grained modeling and dynamics tracking of nanoparticles diffusion in human gut mucus
The gastrointestinal (GI) tract's mucus layer serves as a critical barrier and a mediator in
drug nanoparticle delivery. The mucus layer's diverse molecular structures and spatial …
drug nanoparticle delivery. The mucus layer's diverse molecular structures and spatial …
Experimental and statistical methods for microrheological characterization of heterogeneity in human respiratory mucus mimics of health and disease progression
N Caughman, M Papanikolas, M Markovetz… - Journal of …, 2024 - pubs.aip.org
Human respiratory mucus (HRM) is extremely soft, compelling passive microrheology for
linear viscoelastic characterization. We focus this study on the use of passive microrheology …
linear viscoelastic characterization. We focus this study on the use of passive microrheology …
Entropic lattice Boltzmann model for surface tension effects on liquid plug rupture in two-and three-dimensional channels
We established an entropic lattice Boltzmann model to study surface tension effects on
quasiequilibrium liquid plug rupture in two-and three-dimensional channels. The surface …
quasiequilibrium liquid plug rupture in two-and three-dimensional channels. The surface …
Coarse-grained Modeling and Experimental Investigation of the Viscoelasticity of Human Gut Mucus and Nanoparticle Dynamics
A thick layer of mucus covering the gastrointestinal tract acts as an innate barrier guarding
the epithelial surface. The high molecular weight and cross-linked glycoproteins (mucins) …
the epithelial surface. The high molecular weight and cross-linked glycoproteins (mucins) …
A model-based approach to improve intranasal sprays for respiratory viral infections
Drug delivery for viral respiratory infections, such as SARS-CoV-2, can be enhanced
significantly by targeting the nasopharynx, which is the dominant initial infection site in the …
significantly by targeting the nasopharynx, which is the dominant initial infection site in the …
[HTML][HTML] Statistical Methods for Microrheology of Airway Mucus with Extreme Heterogeneity
N Caughman, M Papanikolas, M Markovetz… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The mucus lining of the human airway epithelium contains two gel-forming mucins, MUC5B
and MUC5AC. During progression of cystic fibrosis (CF), mucus hyper-concentrates as its …
and MUC5AC. During progression of cystic fibrosis (CF), mucus hyper-concentrates as its …
Different relative scalings between transient forces and thermal fluctuations tune regimes of chromatin organization
Within the nucleus, structural maintenance of chromosome protein complexes, namely
condensin and cohesin, create an architecture to facilitate the organization and proper …
condensin and cohesin, create an architecture to facilitate the organization and proper …