Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
Eicosanoids and cancer
D Wang, RN DuBois - Nature Reviews Cancer, 2010 - nature.com
Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that
have been implicated in various pathological processes, such as inflammation and cancer …
have been implicated in various pathological processes, such as inflammation and cancer …
ABC transporters in cancer: more than just drug efflux pumps
JI Fletcher, M Haber, MJ Henderson… - Nature Reviews Cancer, 2010 - nature.com
Multidrug transporter proteins are best known for their contributions to chemoresistance
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …
Pancreatic cancer biology and genetics
N Bardeesy, RA DePinho - Nature Reviews Cancer, 2002 - nature.com
Pancreatic ductal adenocarcinoma is an aggressive and devastating disease, which is
characterized by invasiveness, rapid progression and profound resistance to treatment …
characterized by invasiveness, rapid progression and profound resistance to treatment …
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
JZ Haeggstrom, CD Funk - Chemical reviews, 2011 - ACS Publications
Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …
BLT1 and BLT2: the leukotriene B4 receptors
AM Tager, AD Luster - Prostaglandins, leukotrienes and essential fatty …, 2003 - Elsevier
Two receptors for leukotriene B4 (LTB4) have been molecularly identified: BLT1 and BLT2.
Both receptors are G protein-coupled seven transmembrane domain receptors, whose …
Both receptors are G protein-coupled seven transmembrane domain receptors, whose …
Eosinophils in cancer: favourable or unfavourable?
Eosinophils are granulocytic leukocytes residing in blood and tissues in the lung, breast,
gastrointestinal and reproductive systems. Eosinophilia is uncommon in healthy individuals …
gastrointestinal and reproductive systems. Eosinophilia is uncommon in healthy individuals …
Structure and ligand based drug design strategies in the development of novel 5-LOX inhibitors
Lipoxygenases (LOXs) are non-heme iron containing dioxygenases involved in the
oxygenation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA) …
oxygenation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA) …
Neutrophil extracellular traps (Nets) in cancer metastasis
Simple Summary Neutrophil Extracellular Traps (NETs) are formed following the activation
of neutrophils and play an important role in the development of cancer, especially metastatic …
of neutrophils and play an important role in the development of cancer, especially metastatic …
Therapeutic options for 5-lipoxygenase inhibitors
5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into leukotriene
(LT) A4 and 5-hydroperoxyeicosatetraenoic acid. LTA4 can then be converted into LTB4 by …
(LT) A4 and 5-hydroperoxyeicosatetraenoic acid. LTA4 can then be converted into LTB4 by …