Mechanisms of melatonin in obesity: a review

Q Guan, Z Wang, J Cao, Y Dong, Y Chen - International journal of …, 2021 - mdpi.com
Obesity and its complications have become a prominent global public health problem that
severely threatens human health. Melatonin, originally known as an effective antioxidant, is …

Dietary sources and bioactivities of melatonin

X Meng, Y Li, S Li, Y Zhou, RY Gan, DP Xu, HB Li - Nutrients, 2017 - mdpi.com
Insomnia is a serious worldwide health threat, affecting nearly one third of the general
population. Melatonin has been reported to improve sleep efficiency and it was found that …

Melatonin protects against maternal obesity‐associated oxidative stress and meiotic defects in oocytes via the SIRT 3‐SOD 2‐dependent pathway

L Han, H Wang, L Li, X Li, J Ge… - Journal of pineal …, 2017 - Wiley Online Library
Maternal obesity in humans is associated with poor outcomes across the reproductive
spectrum. Emerging evidence indicates that these defects are likely attributed to factors …

Melatonin in energy control: Circadian time‐giver and homeostatic monitor

E Challet, P Pévet - Journal of Pineal Research, 2024 - Wiley Online Library
Melatonin is a neurohormone synthesized from dietary tryptophan in various organs,
including the pineal gland and the retina. In the pineal gland, melatonin is produced at night …

Melatonin signaling a key regulator of glucose homeostasis and energy metabolism

S Owino, DDC Buonfiglio, C Tchio… - Frontiers in …, 2019 - frontiersin.org
Melatonin, a hormone synthesized by both the pineal gland and retina, functions as an
important modulator of a number of physiological functions. In addition to its rather well …

Inflammaging, metabolic syndrome and melatonin: a call for treatment studies

DP Cardinali, R Hardeland - Neuroendocrinology, 2017 - karger.com
The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease,
including obesity, hypertension, hyperinsulinemia, glucose intolerance and dyslipidemia …

Insight into the roles of melatonin in bone tissue and bone-related diseases

X Lu, S Yu, G Chen, W Zheng… - International …, 2021 - spandidos-publications.com
Bone-related diseases comprise a large group of common diseases, including fractures,
osteoporosis and osteoarthritis (OA), which affect a large number of individuals, particularly …

Ischemic stroke, obesity, and the anti‐inflammatory role of melatonin

N Yawoot, P Govitrapong, C Tocharus, J Tocharus - Biofactors, 2021 - Wiley Online Library
Obesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it.
Pathologies following these conditions are associated with systemic and local inflammation …

Effects of melatonin on cardiovascular risk factors and metabolic syndrome: a comprehensive review

M Imenshahidi, G Karimi, H Hosseinzadeh - … -Schmiedeberg's Archives of …, 2020 - Springer
Melatonin, as a neuroendocrine hormone, is produced primarily by the pineal gland.
Melatonin, a pleotropic molecule, acts as a free radical scavenger, antioxidant, and regulator …

[HTML][HTML] Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and …

D Salagre, M Navarro-Alarcón, M Villalón-Mir… - Biomedicine & …, 2024 - Elsevier
Melatonin acute treatment limits obesity of young Zücker diabetic fatty (ZDF) rats by non-
shivering thermogenesis (NST). We recently showed melatonin chronically increases the …