Anxiety is experienced in response to threats that are distal or uncertain, involving changes
in one's subjective state, autonomic responses, and behavior. Defensive and physiologic …

The Hierarchical Taxonomy of Psychopathology (HiTOP) has emerged out of the
quantitative approach to psychiatric nosology. This approach identifies psychopathology …

In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …

Objective: The purpose of this article was to inform the first-line treatment choice between
cognitive-behavioral therapy (CBT) or an antidepressant medication for treatment-naive …

Anxiety disorders impose a staggering burden on public health, underscoring the need to
develop a deeper understanding of the distributed neural circuits underlying extreme fear …

Non-human primate neuroimaging is a rapidly growing area of research that promises to
transform and scale translational and cross-species comparative neuroscience …

Anxiety disorders and depression are among the most common psychiatric illnesses
affecting youth. Anxiety disorders typically begin in childhood, whereas the onset of …

It is widely thought that phasic and sustained responses to threat reflect dissociable circuits
centered on the central nucleus of the amygdala (Ce) and the bed nucleus of the stria …

The associations among socioeconomic disadvantage, amygdala volume, and internalizing
symptoms in children and adolescents are unclear and understudied in the extant literature …

When extreme, anxiety—a state of distress and arousal prototypically evoked by uncertain
danger—can be debilitating. Uncertain anticipation is a shared feature of situations that elicit …