Machine learning for biologics: opportunities for protein engineering, developability, and formulation
Successful biologics must satisfy multiple properties including activity and particular
physicochemical features that are globally defined as developability. These multiple …
physicochemical features that are globally defined as developability. These multiple …
Non-specificity as the sticky problem in therapeutic antibody development
Antibodies are highly potent therapeutic scaffolds with more than a hundred different
products approved on the market. Successful development of antibody-based drugs …
products approved on the market. Successful development of antibody-based drugs …
Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody
The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population
underscores the need for broadly active countermeasures. We employed a directed …
underscores the need for broadly active countermeasures. We employed a directed …
Biophysical properties of the clinical-stage antibody landscape
T Jain, T Sun, S Durand, A Hall… - Proceedings of the …, 2017 - National Acad Sciences
Antibodies are a highly successful class of biological drugs, with over 50 such molecules
approved for therapeutic use and hundreds more currently in clinical development …
approved for therapeutic use and hundreds more currently in clinical development …
Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes
Snakebite envenoming continues to claim many lives across the globe, necessitating the
development of improved therapies. To this end, broadly-neutralizing human monoclonal …
development of improved therapies. To this end, broadly-neutralizing human monoclonal …
Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning
Antibody development, delivery, and efficacy are influenced by antibody-antigen affinity
interactions, off-target interactions that reduce antibody bioavailability and …
interactions, off-target interactions that reduce antibody bioavailability and …
Predicting antibody developability profiles through early stage discovery screening
M Bailly, C Mieczkowski, V Juan, E Metwally… - MAbs, 2020 - Taylor & Francis
Monoclonal antibodies play an increasingly important role for the development of new drugs
across multiple therapy areas. The term 'developability'encompasses the feasibility of …
across multiple therapy areas. The term 'developability'encompasses the feasibility of …
Assessing developability early in the discovery process for novel biologics
Beyond potency, a good developability profile is a key attribute of a biological drug.
Selecting and screening for such attributes early in the drug development process can save …
Selecting and screening for such attributes early in the drug development process can save …
Developability assessment during the selection of novel therapeutic antibodies
A Jarasch, H Koll, JT Regula, M Bader… - Journal of …, 2015 - Elsevier
Therapeutic antibodies and antibody derivatives comprise the majority of today's
biotherapeutics. Routine methods to generate novel antibodies, such as immunization and …
biotherapeutics. Routine methods to generate novel antibodies, such as immunization and …
A candidate antibody drug for prevention of malaria
KL Williams, S Guerrero, Y Flores-Garcia, D Kim… - Nature medicine, 2024 - nature.com
Over 75% of malaria-attributable deaths occur in children under the age of 5 years.
However, the first malaria vaccine recommended by the World Health Organization (WHO) …
However, the first malaria vaccine recommended by the World Health Organization (WHO) …