Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

Mitochondria are essential organelles with numerous functions in cellular metabolism and
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …

Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes
and plays a role in many mitochondrial processes, including respiration and energy …

Cell division is a complex process with high energy demands. However, how cells regulate
the generation of energy required for DNA synthesis and chromosome segregation is not …

The relationship between metabolism and cell cycle progression is complex and
bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across …

Nearly all mitochondrial proteins are encoded by the nuclear genome and imported into
mitochondria after synthesis on cytosolic ribosomes. These precursor proteins are …

Protein kinase RNA-activated (PKR) induces immune response by sensing viral double-
stranded RNAs (dsRNAs). However, growing evidence suggests that PKR can also be …

We investigated how mitochondrial membrane proteins remain soluble in the cytosol until
their delivery to mitochondria or degradation at the proteasome. We show that Ubiquilin …