[HTML][HTML] Oxidative stress in cancer
Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …
Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements
Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …
ROS production in normal cells is controlled by the appropriate regulation between the silver …
Reactive oxygen species-sources, functions, oxidative damage.
K Jakubczyk, K Dec, J Kałduńska… - Polski merkuriusz …, 2020 - europepmc.org
Reactive oxygen species (ROS) are molecules capable of independent existence,
containing at least one oxygen atom and one or more unpaired electrons. This group …
containing at least one oxygen atom and one or more unpaired electrons. This group …
The multifaceted role of reactive oxygen species in tumorigenesis
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …
various normal cellular functions including cellular growth, differentiation, senescence …
Targeting the thioredoxin system for cancer therapy
Thioredoxin (Trx) and thioredoxin reductase (TrxR) are essential components of the Trx
system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In …
system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In …
Electron-accepting micelles deplete reduced nicotinamide adenine dinucleotide phosphate and impair two antioxidant cascades for ferroptosis-induced tumor …
X Guo, F Liu, J Deng, P Dai, Y Qin, Z Li, B Wang… - ACS …, 2020 - ACS Publications
Ferroptotic antitumor therapy has been compromised by various intracellular antioxidants,
particularly glutathione and thioredoxin. Both are cofactors of glutathione peroxide 4 (GPX4) …
particularly glutathione and thioredoxin. Both are cofactors of glutathione peroxide 4 (GPX4) …
[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis
S Toyokuni, F Ito, K Yamashita, Y Okazaki… - Free Radical Biology …, 2017 - Elsevier
Epidemiological data indicate a constant worldwide increase in cancer mortality, although
the age of onset is increasing. Recent accumulation of genomic data on human cancer via …
the age of onset is increasing. Recent accumulation of genomic data on human cancer via …
The role of thioredoxin system in cancer: strategy for cancer therapy
JJ Jia, WS Geng, ZQ Wang, L Chen… - Cancer chemotherapy and …, 2019 - Springer
Purpose Cancer, a major public health problem, exhibits significant redox alteration.
Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting …
Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting …
Nitric oxide signaling in T cell-mediated immunity
A García-Ortiz, JM Serrador - Trends in molecular medicine, 2018 - cell.com
Nitric oxide (NO) is a key messenger in the pathogenesis of inflammation, linking innate and
adaptive immunity. By targeting signaling molecules, NO from inducible NO synthase (iNOS) …
adaptive immunity. By targeting signaling molecules, NO from inducible NO synthase (iNOS) …