Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

The Martini model, a coarse-grained force field for biomolecular simulations, has found a
broad range of applications since its release a decade ago. Based on a building block …

Antibiotics that target Gram-negative bacteria in new ways are needed to resolve the
antimicrobial resistance crisis,–. Gram-negative bacteria are protected by an additional outer …

Membrane lipid composition varies greatly within submembrane compartments, different
organelle membranes, and also between cells of different cell stage, cell and tissue types …

The coarse-grained Martini model is employed extensively to study membrane protein
oligomerization. While this approach is exceptionally promising given its computational …

Touch, hearing, and blood pressure regulation require mechanically gated ion channels that
convert mechanical stimuli into electrical currents. One such channel is Piezo1, which plays …

In the field of biomolecular simulations, dynamics of phospholipid membranes is of special
interest. A number of proteins, including channels, transporters, receptors and short peptides …

Triacylglycerols (TG) are synthesized at the endoplasmic reticulum (ER) bilayer and
packaged into organelles called lipid droplets (LDs). LDs are covered by a single …

Highlights•Coarse graining allows to model multi-protein aggregates of very large
scale.•Knowledge-based approaches promise to improve protein–protein interface …

Gangliosides are glycolipids in which an oligosaccharide headgroup containing one or
more sialic acids is connected to a ceramide. Gangliosides reside in the outer leaflet of the …