Inducible nitric oxide synthase: Regulation, structure, and inhibition

MA Cinelli, HT Do, GP Miley… - Medicinal research …, 2020 - Wiley Online Library
A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …

[HTML][HTML] Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications

UC Dash, NK Bhol, SK Swain, RR Samal… - … Pharmaceutica Sinica B, 2024 - Elsevier
Neuroprotection is a proactive approach to safeguarding the nervous system, including the
brain, spinal cord, and peripheral nerves, by preventing or limiting damage to nerve cells …

Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

H Kumar, IS Kim, SV More, BW Kim, DK Choi - Natural product reports, 2014 - pubs.rsc.org
Covering: 2000 to 2013 Oxidative stress is the central component of chronic diseases. The
nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway …

Cellular and molecular mediators of neuroinflammation in the pathogenesis of Parkinson's disease

SV More, H Kumar, IS Kim, SY Song… - Mediators of …, 2013 - Wiley Online Library
Neuroinflammation is a host‐defense mechanism associated with restoration of normal
structure and function of the brain and neutralization of an insult. Increasing …

Anti-inflammatory activity of ursolic acid in MPTP-induced parkinsonian mouse model

SN Rai, W Zahra, SS Singh, H Birla, C Keswani… - Neurotoxicity …, 2019 - Springer
Neuroinflammation plays an important role in the progression of Parkinson's disease (PD)
and hence may represent a target for treatment. The drugs used currently for PD only …

Benefits of Cardamom (Elettaria cardamomum (L.) Maton) and Turmeric (Curcuma longa L.) Extracts for Their Applications as Natural Anti-Inflammatory Adjuvants

GR Cárdenas Garza, JH Elizondo Luévano… - Plants, 2021 - mdpi.com
The genus Zingiberaceae has been widely used for phytotherapeutic purposes in traditional
medicine throughout the world for its anti-inflammatory activity. Experimental studies have …

Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways

MO Welcome, NE Mastorakis - Pharmacological research, 2020 - Elsevier
Stress is a nonspecific response to a threat or noxious stimuli with resultant damaging
consequences. Stress is believed to be an underlying process that can trigger central …

Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of …

Y Xu, C Liu, S Chen, Y Ye, M Guo, Q Ren, L Liu… - Cellular signalling, 2014 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopaminergic neurons. Dysregulation of mammalian target of rapamycin (mTOR) has been …

[HTML][HTML] Immunotherapy for Parkinson's disease

AD Schwab, MJ Thurston, J Machhi, KE Olson… - Neurobiology of …, 2020 - Elsevier
With the increasing prevalence of Parkinson's disease (PD), there is an immediate need to
interdict disease signs and symptoms. In recent years this need was met through therapeutic …

Baicalin alleviates lipopolysaccharide-induced liver inflammation in chicken by suppressing TLR4-mediated NF-κB pathway

P Cheng, T Wang, W Li, I Muhammad… - Frontiers in …, 2017 - frontiersin.org
As a kind of potent stimulus, lipopolysaccharide (LPS) has the ability to cause cell damage
by activating toll-like receptor (TLR) 4, then nuclear factor kappa B (NF-κB) translocates into …