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Inducible nitric oxide synthase: Regulation, structure, and inhibition
A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …
[HTML][HTML] Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications
UC Dash, NK Bhol, SK Swain, RR Samal… - … Pharmaceutica Sinica B, 2024 - Elsevier
Neuroprotection is a proactive approach to safeguarding the nervous system, including the
brain, spinal cord, and peripheral nerves, by preventing or limiting damage to nerve cells …
brain, spinal cord, and peripheral nerves, by preventing or limiting damage to nerve cells …
Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
Covering: 2000 to 2013 Oxidative stress is the central component of chronic diseases. The
nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway …
nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway …
Cellular and molecular mediators of neuroinflammation in the pathogenesis of Parkinson's disease
Neuroinflammation is a host‐defense mechanism associated with restoration of normal
structure and function of the brain and neutralization of an insult. Increasing …
structure and function of the brain and neutralization of an insult. Increasing …
Anti-inflammatory activity of ursolic acid in MPTP-induced parkinsonian mouse model
Neuroinflammation plays an important role in the progression of Parkinson's disease (PD)
and hence may represent a target for treatment. The drugs used currently for PD only …
and hence may represent a target for treatment. The drugs used currently for PD only …
Benefits of Cardamom (Elettaria cardamomum (L.) Maton) and Turmeric (Curcuma longa L.) Extracts for Their Applications as Natural Anti-Inflammatory Adjuvants
GR Cárdenas Garza, JH Elizondo Luévano… - Plants, 2021 - mdpi.com
The genus Zingiberaceae has been widely used for phytotherapeutic purposes in traditional
medicine throughout the world for its anti-inflammatory activity. Experimental studies have …
medicine throughout the world for its anti-inflammatory activity. Experimental studies have …
Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways
Stress is a nonspecific response to a threat or noxious stimuli with resultant damaging
consequences. Stress is believed to be an underlying process that can trigger central …
consequences. Stress is believed to be an underlying process that can trigger central …
Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of …
Y Xu, C Liu, S Chen, Y Ye, M Guo, Q Ren, L Liu… - Cellular signalling, 2014 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopaminergic neurons. Dysregulation of mammalian target of rapamycin (mTOR) has been …
dopaminergic neurons. Dysregulation of mammalian target of rapamycin (mTOR) has been …
[HTML][HTML] Immunotherapy for Parkinson's disease
With the increasing prevalence of Parkinson's disease (PD), there is an immediate need to
interdict disease signs and symptoms. In recent years this need was met through therapeutic …
interdict disease signs and symptoms. In recent years this need was met through therapeutic …
Baicalin alleviates lipopolysaccharide-induced liver inflammation in chicken by suppressing TLR4-mediated NF-κB pathway
As a kind of potent stimulus, lipopolysaccharide (LPS) has the ability to cause cell damage
by activating toll-like receptor (TLR) 4, then nuclear factor kappa B (NF-κB) translocates into …
by activating toll-like receptor (TLR) 4, then nuclear factor kappa B (NF-κB) translocates into …