Assisted reproductive technologies (ART) are not yet systematically available to people with
sickle cell disease or their parents. Fertility care for these groups requires addressing sickle …

There is an immediate need to address long‐standing questions about the reproductive
health of girls and women with sickle cell disease (SCD). There are many SCD‐related …

Sickle cell disease (SCD) is a genetic disorder, characterized by hemolytic anemia and vaso‐
occlusive crises (VOCs). Data on the global SCD impact on quality of life (QoL) from the …

Polymerization of deoxygenated hemoglobin S underlies the pathophysiology of sickle cell
disease (SCD). In activating red blood cell pyruvate kinase and glycolysis, mitapivat (AG …

The pathophysiology of sickle cell disease (SCD) is driven by chronic inflammation fueled by
damage associated molecular patterns (DAMPs). We show that elevated cell-free DNA …

Recently, encouraging data provided long-awaited hope for gene therapy as a cure for
sickle cell disease (SCD). Nevertheless, the transient suspension of the bluebird bio gene …

Vaso-occlusive episode (VOE) is a common and critical complication of sickle cell disease
(SCD). Its pathogenesis is incompletely understood. von Willebrand factor (VWF), a …

Most children with sickle cell disease (SCD) today survive into adulthood. Among emerging
adults, there is a marked increase in acute care utilization and a rise in mortality, which can …

Adverse pregnancy outcomes occur frequently in women with sickle cell disease (SCD)
across the globe. In the United States, Black women experience disproportionately worse …

BACKGROUND Curative gene therapies for sickle cell disease (SCD) are currently
undergoing clinical evaluation. The occurrence of myeloid malignancies in these trials has …