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[HTML][HTML] Free fatty acid receptors in health and disease
Fatty acids are metabolized and synthesized as energy substrates during biological
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …
The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution
Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion
injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro …
injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro …
The Concise Guide to PHARMACOLOGY 2013/14: G protein‐coupled receptors
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
Free fatty acids provide an important energy source as nutrients, and act as signalling
molecules in various cellular processes,,,. Several G-protein-coupled receptors have been …
molecules in various cellular processes,,,. Several G-protein-coupled receptors have been …
A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice
DY Oh, E Walenta, TE Akiyama, WS Lagakos… - Nature medicine, 2014 - nature.com
It is well known that the ω–3 fatty acids (ω–3-FAs; also known as n–3 fatty acids) can exert
potent anti-inflammatory effects,,,. Commonly consumed as fish products, dietary …
potent anti-inflammatory effects,,,. Commonly consumed as fish products, dietary …
Complex pharmacology of free fatty acid receptors
G protein-coupled receptors (GPCRs) are historically the most successful family of drug
targets. In recent times it has become clear that the pharmacology of these receptors is far …
targets. In recent times it has become clear that the pharmacology of these receptors is far …
[HTML][HTML] Free fatty acid receptors (FFARs) in adipose: physiological role and therapeutic outlook
Fatty acids (FFAs) are important biological molecules that serve as a major energy source
and are key components of biological membranes. In addition, FFAs play important roles in …
and are key components of biological membranes. In addition, FFAs play important roles in …
G protein-coupled receptors for energy metabolites as new therapeutic targets
CC Blad, C Tang, S Offermanns - Nature reviews Drug discovery, 2012 - nature.com
Several G protein-coupled receptors (GPCRs) that are activated by intermediates of energy
metabolism—such as fatty acids, saccharides, lactate and ketone bodies—have recently …
metabolism—such as fatty acids, saccharides, lactate and ketone bodies—have recently …
Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases
The past decade has seen great progress in the understanding of the molecular
pharmacology, physiological function and therapeutic potential of G-protein-coupled …
pharmacology, physiological function and therapeutic potential of G-protein-coupled …
Free fatty acid receptors as therapeutic targets for the treatment of diabetes
A Ichimura, S Hasegawa, M Kasubuchi… - Frontiers in …, 2014 - frontiersin.org
Nutrition regulates energy balance; however, dysfunction of energy balance can cause
metabolic disorders, such as obesity and diabetes. Fatty acids are an essential energy …
metabolic disorders, such as obesity and diabetes. Fatty acids are an essential energy …