[HTML][HTML] Free fatty acid receptors in health and disease

I Kimura, A Ichimura, R Ohue-Kitano… - Physiological …, 2019 - journals.physiology.org
Fatty acids are metabolized and synthesized as energy substrates during biological
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

CN Serhan, N Chiang, J Dalli - Seminars in immunology, 2015 - Elsevier
Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion
injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro …

The Concise Guide to PHARMACOLOGY 2013/14: G protein‐coupled receptors

SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

A Ichimura, A Hirasawa, O Poulain-Godefroy… - Nature, 2012 - nature.com
Free fatty acids provide an important energy source as nutrients, and act as signalling
molecules in various cellular processes,,,. Several G-protein-coupled receptors have been …

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

DY Oh, E Walenta, TE Akiyama, WS Lagakos… - Nature medicine, 2014 - nature.com
It is well known that the ω–3 fatty acids (ω–3-FAs; also known as n–3 fatty acids) can exert
potent anti-inflammatory effects,,,. Commonly consumed as fish products, dietary …

Complex pharmacology of free fatty acid receptors

G Milligan, B Shimpukade, T Ulven… - Chemical …, 2017 - ACS Publications
G protein-coupled receptors (GPCRs) are historically the most successful family of drug
targets. In recent times it has become clear that the pharmacology of these receptors is far …

[HTML][HTML] Free fatty acid receptors (FFARs) in adipose: physiological role and therapeutic outlook

S Al Mahri, SS Malik, M Al Ibrahim, E Haji, G Dairi… - Cells, 2022 - mdpi.com
Fatty acids (FFAs) are important biological molecules that serve as a major energy source
and are key components of biological membranes. In addition, FFAs play important roles in …

G protein-coupled receptors for energy metabolites as new therapeutic targets

CC Blad, C Tang, S Offermanns - Nature reviews Drug discovery, 2012 - nature.com
Several G protein-coupled receptors (GPCRs) that are activated by intermediates of energy
metabolism—such as fatty acids, saccharides, lactate and ketone bodies—have recently …

Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases

S Talukdar, JM Olefsky, O Osborn - Trends in pharmacological sciences, 2011 - cell.com
The past decade has seen great progress in the understanding of the molecular
pharmacology, physiological function and therapeutic potential of G-protein-coupled …

Free fatty acid receptors as therapeutic targets for the treatment of diabetes

A Ichimura, S Hasegawa, M Kasubuchi… - Frontiers in …, 2014 - frontiersin.org
Nutrition regulates energy balance; however, dysfunction of energy balance can cause
metabolic disorders, such as obesity and diabetes. Fatty acids are an essential energy …