Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …

BACKGROUND AND METHODS: We have reviewed and pooled data from published
studies to evaluate the relationship between microsatellite instability (MSI) and colorectal …

Purpose To update the recommendations for the use of tumor marker tests in the prevention,
screening, treatment, and surveillance of gastrointestinal cancers. Methods For the 2006 …

Purpose These studies were conducted to determine the relationship between quantitative
tumor gene expression and risk of cancer recurrence in patients with stage II or III colon …

Cytokine and growth factor signaling mediates essential roles in the differentiation,
proliferation, survival and function of a number of cell lineages. This is achieved via specific …

BACKGROUND: Microsatellite instability (MSI) status in predicting the efficacy of adjuvant
chemotherapy in colorectal cancer remains controversial. MATERIALS AND METHODS …

Background There is growing evidence that both local and systemic inflammatory responses
play an important role in the progression of a variety of solid tumors. Colorectal cancer …

Rapidly growing insights into the molecular biology of colorectal cancer (CRC) and recent
developments in gene sequencing and molecular diagnostics have led to high expectations …

Background We systematically reviewed the evidence for the interaction of microsatellite
instability status (MSI) and treatment with 5FU in colorectal cancer to determine how well …

Approximately 20 percent of right‐sided colon cancers and 5 percent of left‐sided colon and
rectal cancers have a deficient DNA mismatch repair system. This results in the widespread …