Chronic inflammation generated by the tumor microenvironment is known to drive cancer
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …

Metastatic melanoma is challenging to manage. Although targeted-and immune therapies
have extended survival, most patients experience therapy resistance. The adaptability of …

It is widely accepted that the development of carcinoma—the most common form of human
cancer—is due to the accumulation of somatic mutations in epithelial cells. The behaviour of …

Abstract Interleukin-1 (IL-1) includes a family of closely related genes; the two major
agonistic proteins, IL-1α and IL-1β, are pleiotropic and affect mainly inflammation, immunity …

Skin wounds are a major social and financial burden. However, current treatments are
suboptimal. The gradual comprehension of the finely orchestrated nature of intercellular …

Melanoma is a devastating disease frequently encountered within both veterinary and
human medicine. Molecular changes linked with neoplastic transformation of melanocytes …

Cell to matrix adhesion is a key factor for cellular homeostasis and disruption of such
interaction has adverse effects on cell survival. It leads to a specific type of apoptosis known …

Background Wnt proteins are important for developmental processes and certain diseases.
WNT5A is a non-canonical Wnt protein that previously has been shown to play a role in the …

Purpose: In this study, we assessed the specific role of BRAF (V600E) signaling in
modulating the expression of immune regulatory genes in melanoma, in addition to …

Cell for cell, probably no human cancer is as aggressive as melanoma. It is among a handful
of cancers whose dimensions are reported in millimeters. Tumor thickness approaching 4 …