Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …

Progress has been made in the control or elimination of tropical diseases, with a significant
reduction of incidence. However, there is a risk of re-emergence if the factors fueling …

Background The coronavirus disease 2019 (COVID-19) is a respiratory disease caused by
SARS-CoV-2, a recently discovered strain of coronavirus. The virus has spread rapidly …

The search for new macrofilaricidal drugs against onchocerciasis that can be administered
in shorter regimens than required for doxycycline (DOX, 200mg/d given for 4–6 weeks) …

Despite worldwide mass drug administration, it is estimated that 68 million individuals are
still infected with lymphatic filariasis with 19 million hydrocele and 17 million lymphedema …

The filarial nematode Mansonella perstans is endemic throughout Africa, northern South
America and the Caribbean. Interestingly, M. perstans-infected individuals present no …

Helminths immunomodulate their hosts and induce a regulatory, anti-inflammatory milieu
that prevents allergies and autoimmune diseases. Helminth immunomodulation may benefit …

The prevalence of autoimmune and allergic disorders has dramatically increased in
developed countries, and it is believed that our 'cleaner living'reduces exposure to certain …

Background: There is compelling evidence that not only do anti-filarials significantly reduce
larval forms, but that host immune responses also contribute to the clearance of filarial …

Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4–6 weeks of
doxycycline treatment can lead to permanent sterilization and adult filarial death. We …