mRNA vaccines for infectious diseases: principles, delivery and clinical translation
N Chaudhary, D Weissman… - Nature reviews Drug …, 2021 - nature.com
Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …
mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans
U Sahin, A Muik, I Vogler, E Derhovanessian, LM Kranz… - Nature, 2021 - nature.com
Abstract BNT162b2, a nucleoside-modified mRNA formulated in lipid nanoparticles that
encodes the SARS-CoV-2 spike glycoprotein (S) stabilized in its prefusion conformation, has …
encodes the SARS-CoV-2 spike glycoprotein (S) stabilized in its prefusion conformation, has …
Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera
A Muik, BG Lui, AK Wallisch, M Bacher, J Mühl… - Science, 2022 - science.org
The globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variant of concern Omicron (B. 1.1. 529) has a large number of mutations, especially in the …
variant of concern Omicron (B. 1.1. 529) has a large number of mutations, especially in the …
Unlocking the promise of mRNA therapeutics
E Rohner, R Yang, KS Foo, A Goedel… - Nature biotechnology, 2022 - nature.com
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19)
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …
COVID-19 vaccine development: milestones, lessons and prospects
M Li, H Wang, L Tian, Z Pang, Q Yang… - Signal transduction and …, 2022 - nature.com
With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern
(VOC), the implementation of vaccination is critically important. Existing SARS-CoV-2 …
(VOC), the implementation of vaccination is critically important. Existing SARS-CoV-2 …
Neutralization of SARS-CoV-2 lineage B. 1.1. 7 pseudovirus by BNT162b2 vaccine–elicited human sera
A Muik, AK Wallisch, B Sänger, KA Swanson, J Mühl… - Science, 2021 - science.org
Recently, a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage
called B. 1.1. 7 (variant of concern: VOC 202012/01), which is reported to spread more …
called B. 1.1. 7 (variant of concern: VOC 202012/01), which is reported to spread more …
Bivalent omicron BA. 1–adapted BNT162b2 booster in adults older than 55 years
P Winokur, J Gayed, D Fitz-Patrick… - … England Journal of …, 2023 - Mass Medical Soc
Background The emergence of immune-escape variants of severe acute respiratory
syndrome coronavirus 2 warrants the use of sequence-adapted vaccines to provide …
syndrome coronavirus 2 warrants the use of sequence-adapted vaccines to provide …
[HTML][HTML] Humoral and cellular immune memory to four COVID-19 vaccines
Multiple COVID-19 vaccines, representing diverse vaccine platforms, successfully protect
against symptomatic COVID-19 cases and deaths. Head-to-head comparisons of T cell, B …
against symptomatic COVID-19 cases and deaths. Head-to-head comparisons of T cell, B …
BNT162b2-elicited neutralization of B. 1.617 and other SARS-CoV-2 variants
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve
around the world, generating new variants that are of concern on the basis of their potential …
around the world, generating new variants that are of concern on the basis of their potential …