Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …

Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration
correlates with lower patient survival and resistance to therapy. Tumor-associated …

Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is
appreciated that different tissues instruct specialized macrophage functions. However …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages
(MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We …

Obesity-related metabolic organ inflammation contributes to cardiometabolic disorders. In
obese individuals, changes in lipid fluxes and storage elicit immune responses in the …

Tumor-infiltrating myeloid cells (TIMs) are key regulators in tumor progression, but the
similarity and distinction of their fundamental properties across different tumors remain …