Optogenetic manipulation of neuronal activity through excitatory and inhibitory opsins has
become an indispensable experimental strategy in neuroscience research. For many …

Most patients with inherited retinal degenerations (IRDs) have been waiting for treatments
that are “just around the corner” for decades, with only a handful of seminal breakthroughs …

Gene therapy-based treatment such as optogenetics offers a potentially powerful way to
bypass damaged photoreceptors in retinal degenerative diseases and use the remaining …

Retinal degenerations, such as age-related macular degeneration and retinitis pigmentosa,
present significant challenges due to genetic heterogeneity, limited therapeutic options, and …

Retinal degenerative diseases, such as retinitis pigmentosa (RP) and dry age-related
macular degeneration, have led to loss of vision in millions of individuals. Currently, no …

Vision restoration is one of the most promising applications of optogenetics. However, it is
limited due to the poor-sensitivity, slow-kinetics and narrow band absorption spectra of …

Delivery of therapeutic genes into retina is proving to reverse degeneration and restore
vision, however, viral vector‐based gene delivery is prone to immunorejection …

Since the introduction of Channelrhodopsin-2 (ChR2) to neuroscience, optogenetics
technology was developed, making it possible to activate specific neurons or circuits with …

Perturbation of neural activity by optogenetic means is a powerful approach to probe the
function of defined neuronal populations from the synaptic to the behavioral level. Despite …

Accurately modeling human-related neuronal phenomena remains at the forefront of
neuroscience. This thesis utilizes already-established in vitro models of mouse embryonic …