The human skeleton has remarkable regenerative properties, being one of the few
structures in the body that can heal by recreating its normal cellular composition, orientation …

Abstract β-tricalcium phosphate (β-TCP) is one the most used and potent synthetic bone
graft substitute. It is not only osteoconductive, but also osteoinductive. These properties …

Large injuries to bones are still one of the most challenging musculoskeletal problems.
Tissue engineering can combine stem cells, scaffold biomaterials, and biofactors to aid in …

Various types of materials have been traditionally used to restore damaged bones. In the
late 1960s, a strong interest was raised in studying ceramics as potential bone grafts due to …

An ideal periosteum substitute should be able to mimic the periosteum microenvironment
that continuously provides growth factors, recruits osteoblasts, and subsequent extracellular …

With the increase of global population, people's life expectancy is growing as well. Humans
tend to live more active lifestyles and, therefore, trauma generated large defects become …

For the past 20 years, the democratization of additive manufacturing (AM) technologies has
made many of us dream of: low cost, waste-free, and on-demand production of functional …

Abstract β-Tricalcium Phosphate (β-TCP), one of the most used bone graft substitutes, may
contain up to 5 wt% foreign phase according to standards. Typical foreign phases include β …

It is significant to use functional biomaterials to rationally engineer microenvironments for in
situ bone regeneration in the field of bone tissue engineering. To this end, we constructed …

Heterotopic ossification (HO) is a condition triggered by an injury leading to the formation of
mature lamellar bone in extraskeletal soft tissues. Despite being a frequent complication of …