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Strategies to overcome antimicrobial resistance (AMR) making use of non-essential target inhibitors: A review
G Annunziato - International journal of molecular sciences, 2019 - mdpi.com
Antibiotics have always been considered as one of the most relevant discoveries of the
twentieth century. Unfortunately, the dawn of the antibiotic era has sadly corresponded to the …
twentieth century. Unfortunately, the dawn of the antibiotic era has sadly corresponded to the …
Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?
Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …
have modified their virulence mechanisms to adapt to host defense systems. Although the …
Dual RNA-seq unveils noncoding RNA functions in host–pathogen interactions
Bacteria express many small RNAs for which the regulatory roles in pathogenesis have
remained poorly understood due to a paucity of robust phenotypes in standard virulence …
remained poorly understood due to a paucity of robust phenotypes in standard virulence …
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
Novel classes of antibiotics or more of the same?
ARM Coates, G Halls, Y Hu - British journal of pharmacology, 2011 - Wiley Online Library
The world is running out of antibiotics. Between 1940 and 1962, more than 20 new classes
of antibiotics were marketed. Since then, only two new classes have reached the market …
of antibiotics were marketed. Since then, only two new classes have reached the market …
[HTML][HTML] Dysbiosis-associated change in host metabolism generates lactate to support Salmonella growth
During Salmonella-induced gastroenteritis, mucosal inflammation creates a niche that favors
the expansion of the pathogen population over the microbiota. Here, we show that …
the expansion of the pathogen population over the microbiota. Here, we show that …
Antibiotic-resistant bacteria: a challenge for the food industry
Antibiotic-resistant bacteria were first described in the 1940s, but whereas new antibiotics
were being discovered at a steady rate, the consequences of this phenomenon were slow to …
were being discovered at a steady rate, the consequences of this phenomenon were slow to …
Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
Conventional wisdom holds that microbes support their growth in vertebrate hosts by
exploiting a large variety of nutrients. We show here that use of a specific nutrient …
exploiting a large variety of nutrients. We show here that use of a specific nutrient …
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
Abstract CD4+ type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal
role in promoting and maintaining tolerance. The absence of surface markers that uniquely …
role in promoting and maintaining tolerance. The absence of surface markers that uniquely …
Decline in nitrosative stress drives antibiotic persister regrowth during infection
Internalization of pathogenic bacteria by macrophages results in formation of antibiotic-
tolerant persisters. These cells are maintained in a non-growing state for extended periods …
tolerant persisters. These cells are maintained in a non-growing state for extended periods …