[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
Pathological mechanisms of bortezomib-induced peripheral neuropathy
S Yamamoto, N Egashira - International journal of molecular sciences, 2021 - mdpi.com
Bortezomib, a first-generation proteasome inhibitor widely used in chemotherapy for
hematologic malignancy, has effective anti-cancer activity but often causes severe …
hematologic malignancy, has effective anti-cancer activity but often causes severe …
Involvement of Opioid System and TRPM8/TRPA1 Channels in the Antinociceptive Effect of Spirulina platensis
MA Freitas, A Vasconcelos, ECD Gonçalves… - Biomolecules, 2021 - mdpi.com
Spirulina platensis is a “super-food” and has attracted researchers' attention due to its anti-
inflammatory, antioxidant, and analgesic properties. Herein, we investigated the …
inflammatory, antioxidant, and analgesic properties. Herein, we investigated the …
Naringenin reduces inflammatory pain in mice
Naringenin is a flavonoid widely consumed by humans that present anti-inflammatory
activity and low toxicity. Recently, the analgesic effect of naringenin has been demonstrated …
activity and low toxicity. Recently, the analgesic effect of naringenin has been demonstrated …
TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice
IM Marone, F De Logu, R Nassini… - Brain, 2018 - academic.oup.com
Glyceryl trinitrate is administered as a provocative test for migraine pain. Glyceryl trinitrate
causes prolonged mechanical allodynia in rodents, which temporally correlates with …
causes prolonged mechanical allodynia in rodents, which temporally correlates with …
The role of TRP ion channels in migraine and headache
Migraine afflicts more than 10% of the general population. Although its mechanism is poorly
understood, recent preclinical and clinical evidence has identified calcitonin gene related …
understood, recent preclinical and clinical evidence has identified calcitonin gene related …
Migraine treatment: Towards new pharmacological targets
M Silvestro, LF Iannone, I Orologio, A Tessitore… - International Journal of …, 2023 - mdpi.com
Migraine is a debilitating neurological condition affecting millions of people worldwide. Until
a few years ago, preventive migraine treatments were based on molecules with pleiotropic …
a few years ago, preventive migraine treatments were based on molecules with pleiotropic …
TRP channels in cancer: signaling mechanisms and translational approaches
M Marini, M Titiz, D Souza Monteiro de Araújo… - Biomolecules, 2023 - mdpi.com
Ion channels play a crucial role in a wide range of biological processes, including cell cycle
regulation and cancer progression. In particular, the transient receptor potential (TRP) family …
regulation and cancer progression. In particular, the transient receptor potential (TRP) family …
Environmental occurrence, risk, and removal strategies of pyrazolones: A critical review
Pyrazolones, widely used as analgesic and anti-inflammatory pharmaceuticals, have
become a significant concern because of their persistence and widespread presence in …
become a significant concern because of their persistence and widespread presence in …
Nobel somatosensations and pain
Abstract The Nobel prices 2021 for Physiology and Medicine have been awarded to David
Julius and Ardem Patapoutian" for their discoveries of receptors for temperature and touch" …
Julius and Ardem Patapoutian" for their discoveries of receptors for temperature and touch" …