Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …

As populations diverge, genetic differences accumulate across the genome. Spurred by
rapid developments in sequencing technology, genome-wide population surveys of natural …

High-quality and complete reference genome assemblies are fundamental for the
application of genomics to biology, disease, and biodiversity conservation. However, such …

Motivation The emergence of high-throughput sequencing technologies revolutionized
genomics in early 2000s. The next revolution came with the era of long-read sequencing …

The human reference genome assembly plays a central role in nearly all aspects of today's
basic and clinical research. GRCh38 is the first coordinate-changing assembly update since …

While genome assembly projects have been successful in many haploid and inbred
species, the assembly of noninbred or rearranged heterozygous genomes remains a major …

Long-read de novo genome assembly continues to advance rapidly. However, there is a
lack of effective tools to accurately evaluate the assembly results, especially for structural …

Whole-genome sequences are now available for many microbial species and clades,
however existing whole-genome alignment methods are limited in their ability to perform …

Limitations of genome sequencing techniques have led to dozens of assembly algorithms,
none of which is perfect. A number of methods for comparing assemblers have been …

Most current approaches for analyzing metagenomic data rely on comparisons to reference
genomes, but the microbial diversity of many environments extends far beyond what is …