Skin aging, cellular senescence and natural polyphenols
E Csekes, L Račková - International journal of molecular sciences, 2021 - mdpi.com
The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …
impacting its morphology and function. Senescent cells have been found to accumulate with …
Hallmarks of cellular senescence
A Hernandez-Segura, J Nehme, M Demaria - Trends in cell biology, 2018 - cell.com
Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …
remodeling during development and after injury, but can also contribute to the decline of the …
p21 in cancer research
B Shamloo, S Usluer - Cancers, 2019 - mdpi.com
p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is
dysregulated in some cancers. Earlier observations on p21 knockout models emphasized …
dysregulated in some cancers. Earlier observations on p21 knockout models emphasized …
Ageing, cellular senescence and neurodegenerative disease
Ageing is a major risk factor for develo** many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …
senescence is a homeostatic biological process that has a key role in driving ageing. There …
Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage
An appropriate control over cell cycle progression depends on many factors. Cyclin-
dependent kinase (CDK) inhibitor p21 (also known as p21 WAF1/Cip1) is one of these …
dependent kinase (CDK) inhibitor p21 (also known as p21 WAF1/Cip1) is one of these …
The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy
NN Kreis, F Louwen, J Yuan - Cancers, 2019 - mdpi.com
Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …
Cellular senescence: from mechanisms to current biomarkers and senotherapies
V Lucas, C Cavadas, CA Aveleira, V Hook - Pharmacological Reviews, 2023 - Elsevier
An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …
related diseases. In the last few decades, several studies have provided evidence of the …
LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint
N Dimitrova, JR Zamudio, RM Jong, D Soukup… - Molecular cell, 2014 - cell.com
The p53-regulated long noncoding RNA lincRNA-p21 has been proposed to act in trans via
several mechanisms ranging from repressing genes in the p53 transcriptional network to …
several mechanisms ranging from repressing genes in the p53 transcriptional network to …
The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics
p21 cip1/waf1 mediates various biological activities by sensing and responding to multiple
stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor …
stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor …
[HTML][HTML] Patterns of early p21 dynamics determine proliferation-senescence cell fate after chemotherapy
Chemotherapy is designed to induce cell death. However, at non-lethal doses, cancer cells
can choose to remain proliferative or become senescent. The slow development of …
can choose to remain proliferative or become senescent. The slow development of …