Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus
D Ferguson, BN Finck - Nature Reviews Endocrinology, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease
in the world, yet there are still no approved pharmacological therapies to prevent or treat this …
in the world, yet there are still no approved pharmacological therapies to prevent or treat this …
NAFLD: mechanisms, treatments, and biomarkers
F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …
AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease
Abbreviations: AASLD, American Association for the Study of Liver Diseases; AI, artificial
intelligence; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUROC …
intelligence; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUROC …
Therapeutic pipeline in nonalcoholic steatohepatitis
Our understanding of nonalcoholic fatty liver disease pathophysiology continues to advance
rapidly. Accordingly, the field has moved from describing the clinical phenotype through the …
rapidly. Accordingly, the field has moved from describing the clinical phenotype through the …
The effects of type 2 diabetes mellitus on organ metabolism and the immune system
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …
Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis
H Li, XH Yu, X Ou, XP Ouyang, CK Tang - Progress in lipid research, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …
representing the most common chronic liver disease in the world. Atherosclerotic …
Obesity and nonalcoholic fatty liver disease: current perspectives
R Sarwar, N Pierce, S Koppe - Diabetes, metabolic syndrome and …, 2018 - Taylor & Francis
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of
chronic liver disease due to an increase in the prevalence of obesity. The development of …
chronic liver disease due to an increase in the prevalence of obesity. The development of …
[HTML][HTML] Role of XBP1 in regulating the progression of non-alcoholic steatohepatitis
Q Wang, H Zhou, Q Bu, S Wei, L Li, J Zhou, S Zhou… - Journal of …, 2022 - Elsevier
Background & Aims Non-alcoholic steatohepatitis (NASH) is associated with the
dysregulation of lipid metabolism and hepatic inflammation, though the underlying …
dysregulation of lipid metabolism and hepatic inflammation, though the underlying …
Nonalcoholic fatty liver disease and hypercholesterolemia: roles of thyroid hormones, metabolites, and agonists
Background: Thyroid hormones (THs) exert a strong influence on mammalian lipid
metabolism at the systemic and hepatic levels by virtue of their roles in regulating circulating …
metabolism at the systemic and hepatic levels by virtue of their roles in regulating circulating …
The molecular mechanisms of liver fibrosis and its potential therapy in application
D Zhang, Y Zhang, B Sun - International Journal of Molecular Sciences, 2022 - mdpi.com
Liver fibrosis results from repeated and persistent liver damage. It can start with hepatocyte
injury and advance to inflammation, which recruits and activates additional liver immune …
injury and advance to inflammation, which recruits and activates additional liver immune …