Exosomal circRNA serves a novel genetic information molecule, facilitating communication
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …

Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …

Over the past decades, cancer immunotherapy has encountered challenges such as
immunogenicity, inefficiency, and cytotoxicity. Consequently, exosome-based cancer …

Introduction Understanding the interactions between administered nanoparticles and the
liver is crucial for develo** safe and effective nanomedicines. As the liver can sequester …

Endothelial cells (ECs) are pivotal in maintaining vascular health, regulating hemodynamics,
and modulating inflammatory responses. Nanocarriers hold transformative potential for …

In vivo genome correction holds promise for generating durable disease cures; yet, effective
stem cell editing remains challenging. In this work, we demonstrate that optimized lung …

In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor
immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great …

The biomedical use of nanoparticles (NPs) has been the focus of intense research for over a
decade. As most NPs are explored as carriers to alter the biodistribution, pharmacokinetics …

Over the past decade, in vivo gene replacement therapy has significantly advanced,
resulting in market approval of numerous therapeutics predominantly relying on adeno …

Dysfunction of endothelial cells (ECs) lining the inner surface of blood vessels are causative
for a number of diseases. Hence, the ability to therapeutically modulate gene expression …