The protein tyrosine kinase focal adhesion kinase (FAK) plays a prominent role in integrin
signaling. FAK activation, demonstrated by an increase in phosphorylation of Tyr397 as well …

First described 15 years ago as a cysteine-rich sequence that was common to a small group
of homeodomain transcription factors, the LIM domain is now recognized as a tandem zinc …

Tumor cells exhibit two different modes of individual cell movement. Mesenchymal-type
movement is characterized by an elongated cellular morphology and requires extracellular …

The mammalian cilium protrudes from the apical/lumenal surface of polarized cells and acts
as a sensor of environmental cues. Numerous developmental disorders and pathological …

▪ Abstract The guidance of axons during the establishment of the nervous system is
mediated by a variety of extracellular cues that govern cytoskeletal dynamics in axonal …

Engagement of integrin receptors with extracellular ligands gives rise to the formation of
complex multiprotein structures that link the ECM to the cytoplasmic actin cytoskeleton …

The focal adhesion kinase, FAK, is an important component of an integrin-dependent
signaling pathway, which functions to transmit signals from the extracellular matrix into the …

Crk family adaptors are widely expressed and mediate the timely formation of signal
transduction protein complexes upon a variety of extracellular stimuli, including various …

Genomes of human cancer cells are characterized by numerous chromosomal aberrations
of uncertain pathogenetic significance. Here, in an inducible mouse model of melanoma, we …

▪ Abstract Cells adhere to the extracellular matrix throughout most of their lifetime. This close,
intimate contact with the matrix exerts an extraordinary control on the behavior of cells …