Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …

Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous, unpredictable and ultimately
lethal chronic lung disease. Over the last decade, two anti-fibrotic agents have been shown …

Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …

Data generated by genome-wide association studies (GWAS) are growing fast with the
linkage of biobank samples to health records, and expanding capture of high-dimensional …

This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …

Aims Low vitamin D status is associated with a higher risk for cardiovascular diseases
(CVDs). Although most existing linear Mendelian randomization (MR) studies reported a null …

Background Variation in liability to cannabis use disorder has a strong genetic component
(estimated twin and family heritability about 50–70%) and is associated with negative …

Genetic association results are often interpreted with the assumption that study participation
does not affect downstream analyses. Understanding the genetic basis of participation bias …

Background Low vitamin D status is often associated with systemic low-grade inflammation
as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and …

Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because
it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for …