Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes.
A complex formed by six telomere-specific proteins associates with this sequence and …

Telomeres play a central role in cell fate and aging by adjusting the cellular response to
stress and growth stimulation on the basis of previous cell divisions and DNA damage. At …

Telomeres are nucleoprotein structures that cap the end of each chromosome arm and
function to maintain genome stability. The length of telomeres is known to shorten with each …

Alternative lengthening of telomeres (ALT) is a telomerase-independent but recombination-
dependent pathway that maintains telomeres. Here, we describe an assay to visualize ALT …

Eukaryotic DNA is bound and interpreted by numerous protein complexes in the context of
chromatin. A description of the full set of proteins that regulate specific loci is critical to …

Telomerase negative immortal cancer cells elongate telomeres through the Alternative
Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is …

To escape replicative senescence, cancer cells have to overcome telomere attrition during
DNA replication. Most of cancers rely on telomerase to extend and maintain telomeres, but 4 …

Activation of a telomere maintenance mechanism (TMM) is permissive for replicative
immortality and a hallmark of human cancer. While most cancers rely on reactivation of …

Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere
maintenance mechanism that occurs in a subset of cancers. One of the hallmarks of ALT …

Stem cells and cancer cells maintain telomere length mostly through telomerase,,.
Telomerase activity is high in male germ line and stem cells, but is low or absent in mature …