What can be expected in normal aging, and where does normal aging stop and pathological
neurodegeneration begin? With the slow progression of age-related dementias such as …

Some individuals are able to maintain their cognitive abilities despite the presence of
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …

Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer's
disease, but the functional brain mechanisms that support cognitive resilience remain …

A common finding in human functional brain-imaging studies is that damage to neural
systems paradoxically results in enhanced functional connectivity between network regions …

Higher educational attainment is observationally associated with lower risk of Alzheimer's
disease. However, the biological mechanisms underpinning this association remain unclear …

Studies of brain network connectivity improved understanding on brain changes and
adaptation in response to different pathologies. Synaptic plasticity, the ability of neurons to …

Cognitive reserve (CR) prevents cognitive decline and delays neurodegeneration. Recent
epidemiological evidence suggests that lifelong bilingualism may act as CR delaying the …

Background Alzheimer's disease (AD) is a neurodegenerative disorder with significant
heterogeneity. Different AD phenotypes may be associated with specific brain network …

Background: Effective interventions are needed to improve brain function in mild cognitive
impairment (MCI), an early stage of Alzheimer's disease (AD). The posterior cingulate cortex …

Recent studies in mouse models of Alzheimer's disease (AD) and in humans suggest that
sleep disruption and amyloid-beta (Aβ) accumulation are interrelated, and may, thus …