Nonlinear and stochastic dynamics in the heart
In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …
Computational models for calcium-mediated astrocyte functions
T Manninen, R Havela, ML Linne - Frontiers in computational …, 2018 - frontiersin.org
The computational neuroscience field has heavily concentrated on the modeling of neuronal
functions, largely ignoring other brain cells, including one type of glial cell, the astrocytes …
functions, largely ignoring other brain cells, including one type of glial cell, the astrocytes …
Imaging single-cell signaling dynamics with a deterministic high-density single-cell trap array
Stochasticity in gene expression, protein or metabolite levels contributes to cell–cell
variations, the analysis of which could lead to a better understanding of cellular processes …
variations, the analysis of which could lead to a better understanding of cellular processes …
Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity
Astrocytes, a glial cell type of the central nervous system, have emerged as detectors and
regulators of neuronal information processing. Astrocyte excitability resides in transient …
regulators of neuronal information processing. Astrocyte excitability resides in transient …
Interplay Between Intracellular Ca2+ Oscillations and Ca2+-stimulated Mitochondrial Metabolism
Oscillations of cytosolic Ca2+ concentration are a widespread mode of signalling. Oscillatory
spikes rely on repetitive exchanges of Ca2+ between the endoplasmic reticulum (ER) and …
spikes rely on repetitive exchanges of Ca2+ between the endoplasmic reticulum (ER) and …
Reliable Encoding of Stimulus Intensities Within Random Sequences of Intracellular Ca2+ Spikes
Ca2+ is a ubiquitous intracellular messenger that regulates diverse cellular activities.
Extracellular stimuli often evoke sequences of intracellular Ca2+ spikes, and spike …
Extracellular stimuli often evoke sequences of intracellular Ca2+ spikes, and spike …
Intracellular oscillations and waves
C Beta, K Kruse - Annual Review of Condensed Matter Physics, 2017 - annualreviews.org
Dynamic processes in living cells are highly organized in space and time. Unraveling the
underlying molecular mechanisms of spatiotemporal pattern formation remains one of the …
underlying molecular mechanisms of spatiotemporal pattern formation remains one of the …
Cooperativity in cellular biochemical processes: noise-enhanced sensitivity, fluctuating enzyme, bistability with nonlinear feedback, and other mechanisms for …
H Qian - Annual review of biophysics, 2012 - annualreviews.org
Cooperativity in classical biophysics originates from molecular interactions; nonlinear
feedbacks in biochemical networks regulate dynamics inside cells. Using stochastic reaction …
feedbacks in biochemical networks regulate dynamics inside cells. Using stochastic reaction …
Criticality in intracellular calcium signaling in cardiac myocytes
Calcium (Ca) is a ubiquitous second messenger that regulates many biological functions.
The elementary events of local Ca signaling are Ca sparks, which occur randomly in time …
The elementary events of local Ca signaling are Ca sparks, which occur randomly in time …
Thermodynamics of chemical waves
Chemical waves constitute a known class of dissipative structures emerging in reaction-
diffusion systems. They play a crucial role in biology, spreading information rapidly to …
diffusion systems. They play a crucial role in biology, spreading information rapidly to …