The fight against cancer by microgravity: the multicellular spheroid as a metastasis model

D Grimm, H Schulz, M Krüger… - International Journal of …, 2022 - mdpi.com
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …

Modeling the impact of microgravity at the cellular level: implications for human disease

P Bradbury, H Wu, JU Choi, AE Rowan… - Frontiers in cell and …, 2020 - frontiersin.org
A lack of gravity experienced during space flight has been shown to have profound effects
on human physiology including muscle atrophy, reductions in bone density and immune …

The role of the cytoskeleton in sensing changes in gravity by nonspecialized cells

D Vorselen, WH Roos, FC MacKintosh… - The FASEB …, 2014 - Wiley Online Library
A large body of evidence indicates that single cells in vitro respond to changes in gravity,
and that this response might play an important role for physiological changes at the …

Using space-based investigations to inform cancer research on Earth

JL Becker, GR Souza - Nature Reviews Cancer, 2013 - nature.com
Experiments conducted in the microgravity environment of space are not typically at the
forefront of the mind of a cancer biologist. However, space provides physical conditions that …

Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells

MZ Nassef, S Kopp, M Wehland, D Melnik… - International journal of …, 2019 - mdpi.com
With the increasing number of spaceflights, it is crucial to understand the changes occurring
in human cells exposed to real microgravity (r-µ g) conditions. We tested the effect of r-µ g on …

Alterations of the cytoskeleton in human cells in space proved by life-cell imaging

TJ Corydon, S Kopp, M Wehland, M Braun, A Schütte… - Scientific reports, 2016 - nature.com
Microgravity induces changes in the cytoskeleton. This might have an impact on cells and
organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity …

The effects of weightlessness on the human organism and mammalian cells

J Pietsch, J Bauer, M Egli, M Infanger… - Current molecular …, 2011 - ingentaconnect.com
It has always been a desire of mankind to conquest Space. A major step in realizing this
dream was the completion of the International Space Station (ISS). Living there for several …

[HTML][HTML] Endothelial stress by gravitational unloading: effects on cell growth and cytoskeletal organization

SIM Carlsson, MTS Bertilaccio, E Ballabio… - Biochimica et Biophysica …, 2003 - Elsevier
All organisms on Earth have evolved to survive within the pull of gravity. Orbital space flights
have clearly demonstrated that the absence or the reduction of gravity profoundly affects …

Function of the cytoskeleton in gravisensing during spaceflight

M Hughes-Fulford - Advances in Space Research, 2003 - Elsevier
Since astronauts and cosmonauts have significant bone loss in microgravity we
hypothesized that there would be physiological changes in cellular bone growth and …

Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells

R Singh, M Rajput, RP Singh - Mitochondrion, 2021 - Elsevier
The weightlessness or microgravity, a physical factor in space, may adversely affect the
health of the space travellers or astronauts. The knowledge about the effect of microgravity …