The fight against cancer by microgravity: the multicellular spheroid as a metastasis model
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …
Modeling the impact of microgravity at the cellular level: implications for human disease
A lack of gravity experienced during space flight has been shown to have profound effects
on human physiology including muscle atrophy, reductions in bone density and immune …
on human physiology including muscle atrophy, reductions in bone density and immune …
The role of the cytoskeleton in sensing changes in gravity by nonspecialized cells
A large body of evidence indicates that single cells in vitro respond to changes in gravity,
and that this response might play an important role for physiological changes at the …
and that this response might play an important role for physiological changes at the …
Using space-based investigations to inform cancer research on Earth
JL Becker, GR Souza - Nature Reviews Cancer, 2013 - nature.com
Experiments conducted in the microgravity environment of space are not typically at the
forefront of the mind of a cancer biologist. However, space provides physical conditions that …
forefront of the mind of a cancer biologist. However, space provides physical conditions that …
Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells
With the increasing number of spaceflights, it is crucial to understand the changes occurring
in human cells exposed to real microgravity (r-µ g) conditions. We tested the effect of r-µ g on …
in human cells exposed to real microgravity (r-µ g) conditions. We tested the effect of r-µ g on …
Alterations of the cytoskeleton in human cells in space proved by life-cell imaging
Microgravity induces changes in the cytoskeleton. This might have an impact on cells and
organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity …
organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity …
The effects of weightlessness on the human organism and mammalian cells
J Pietsch, J Bauer, M Egli, M Infanger… - Current molecular …, 2011 - ingentaconnect.com
It has always been a desire of mankind to conquest Space. A major step in realizing this
dream was the completion of the International Space Station (ISS). Living there for several …
dream was the completion of the International Space Station (ISS). Living there for several …
[HTML][HTML] Endothelial stress by gravitational unloading: effects on cell growth and cytoskeletal organization
SIM Carlsson, MTS Bertilaccio, E Ballabio… - Biochimica et Biophysica …, 2003 - Elsevier
All organisms on Earth have evolved to survive within the pull of gravity. Orbital space flights
have clearly demonstrated that the absence or the reduction of gravity profoundly affects …
have clearly demonstrated that the absence or the reduction of gravity profoundly affects …
Function of the cytoskeleton in gravisensing during spaceflight
M Hughes-Fulford - Advances in Space Research, 2003 - Elsevier
Since astronauts and cosmonauts have significant bone loss in microgravity we
hypothesized that there would be physiological changes in cellular bone growth and …
hypothesized that there would be physiological changes in cellular bone growth and …
Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells
The weightlessness or microgravity, a physical factor in space, may adversely affect the
health of the space travellers or astronauts. The knowledge about the effect of microgravity …
health of the space travellers or astronauts. The knowledge about the effect of microgravity …