Ischemia-reperfusion (I/R) injury is a major challenge in perioperative medicine that
contributes to pathological damage in various conditions, including ischemic stroke …

The high-throughput, high-resolution phenoty** enabled by metabolomics has been
applied increasingly to a variety of questions in nephrology research. This article provides …

Metabolomic approaches have begun to catalog the metabolic disturbances that accompany
CKD, but whether metabolite alterations can predict future CKD is unknown. We performed …

Kidney transplant injury occurs with ischemia and alloimmunity. Members of the receptor
interacting protein kinase family (RIPK1, 3) are key regulators of “necroptosis,” a newly …

Background: The kynurenine pathway (KP) is the major catabolic pathway for tryptophan
degradation. The KP plays an important role as the sole de novo nicotinamide adenine …

Abstract Background. Tryptophan (Trp) is catabolized by indoleamine 2, 3-dioxygenase
(IDO). Changes in Trp metabolism and IDO activity in chronic kidney disease (CKD) have …

Objective: Type 2 diabetes (T2D) is the primary case of chronic kidney disease (CKD).
Inflammation is associated with metabolic dysregulation in patients with T2D and CKD …

Systemic inflammation (SI) is involved in the pathogenesis of acute decompensation (AD)
and acute‐on‐chronic liver failure (ACLF) in cirrhosis. In other diseases, SI activates …

Cardiovascular disease (CVD) is one of the major causes of mortality worldwide.
Inflammation is the underlying common mechanism involved in CVD. It has been recently …

Kidney diseases have become one of the most common health care problems. Due to a
growing number of advanced aged patients with concomitant disorders the prevalence of …