Insect cytochrome P450 monooxygenases (P450s) perform a variety of important
physiological functions, but it is their role in the detoxification of xenobiotics, such as natural …

Threatening the global community is a wide variety of potential threats, most notably
invasive pest species. Invasive pest species are non-native organisms that humans have …

Both Aedes aegytpi and Ae. albopictus are major vectors of 5 important arboviruses (namely
chikungunya virus, dengue virus, Rift Valley fever virus, yellow fever virus, and Zika virus) …

Highlights•Cuticular resistance is due to cuticle thickening and its altered
composition.•Cuticular alterations can increase the intensity and broaden the spectrum of …

The P450 family (CYP genes) of arthropods encodes diverse enzymes involved in the
metabolism of foreign compounds and in essential endocrine or ecophysiological functions …

Human pathogens that are transmitted by insects are a global problem, particularly those
vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species …

Insect cuticular hydrocarbons (CHCs) consist of complex mixtures of straight-chain alkanes
and alkenes, and methyl-branched hydrocarbons. In addition to restricting water loss …

Pyrethroids are a class of highly effective, broad-spectrum, less toxic, biodegradable
synthetic pesticides. However, despite the extremely wide application of pyrethroids, there …

To tackle the problem of insecticide resistance, all resistance mechanisms need to be
studied. This study investigated the involvement of the cuticle in pyrethroid resistance in a …

Despite the substantial progress achieved in the characterization of cytochrome P450 (CYP)-
based resistance mechanisms in mosquitoes, a number of questions remain unanswered …