The role of malate dehydrogenase (MDH) in the metabolism of various medically significant
protozoan parasites is reviewed. MDH is an NADH-dependent oxidoreductase that …

Post-infectious conditions present major health burdens but remain poorly understood. In
Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that …

Highlights•T. cruzi amastigotes can dynamically respond to changes in their
environment.•Growth and metabolic flexibility allow for T. cruzi growth in diverse …

Trypanosoma cruzi, a flagellated protozoan, is the causative agent of Chagas disease. The
parasite has developed various mechanisms to get through its intricate life cycle and adapt …

Leishmania is an intracellular parasite with different species pathogenic to humans and
causing the disease leishmaniasis. Leishmania donovani causes visceral leishmaniasis …

Protozoan parasite infection dramatically alters host metabolism, driven by immunological
demand and parasite manipulation strategies. Immunometabolic checkpoints are often …

Leishmania is an intracellular protozoan transmitted by sand fly vectors; it causes
cutaneous, mucocutaneous, or visceral disease. Its growth and survival are impeded by type …

Post-infectious conditions, where clinical symptoms fail to resolve even after pathogen
clearance, present major health burdens. However, the mechanisms involved remain poorly …

Studies of drug resistance in the protozoan parasites of the genus Leishmania have been
helpful in revealing biochemical pathways as potential drug targets. The chlorinated …

Pathogen tropism and disease tropism refer to the tissue locations selectively colonized or
damaged by pathogens, leading to localized disease symptoms. Human-infective …