The PI3K-AKT-mTOR pathway and prostate cancer: at the crossroads of AR, MAPK, and WNT signaling
BY Shorning, MS Dass, MJ Smalley… - International journal of …, 2020 - mdpi.com
Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …
Targeting the PI3K/AKT/mTOR signaling pathway in the treatment of human diseases: Current status, trends, and solutions
J Huang, L Chen, J Wu, D Ai, JQ Zhang… - Journal of medicinal …, 2022 - ACS Publications
The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR) pathway is one of the most important intracellular pathways involved in …
rapamycin (mTOR) pathway is one of the most important intracellular pathways involved in …
Molecular biomarkers in localized prostate cancer: ASCO guideline
PURPOSE This guideline provides recommendations for available tissue-based prostate
cancer biomarkers geared toward patient selection for active surveillance, identification of …
cancer biomarkers geared toward patient selection for active surveillance, identification of …
PTEN regulates PI (3, 4) P2 signaling downstream of class I PI3K
M Malek, A Kielkowska, T Chessa, KE Anderson… - Molecular cell, 2017 - cell.com
The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in
cancer. Class I PI3Ks synthesize the lipid messenger PI (3, 4, 5) P 3. PI (3, 4, 5) P 3 can be …
cancer. Class I PI3Ks synthesize the lipid messenger PI (3, 4, 5) P 3. PI (3, 4, 5) P 3 can be …
Phosphoinositides in new spaces
EM Davies, CA Mitchell… - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Phosphoinositides (PIs) are phospholipids derived from phosphatidylinositol. PIs are
regulated via reversible phosphorylation, which is directed by the opposing actions of PI …
regulated via reversible phosphorylation, which is directed by the opposing actions of PI …
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Abstract INPP4B suppresses PI3K/AKT signaling by converting PI (3, 4) P2 to PI (3) P and
INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is …
INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is …
PI (3, 4) P2 signaling in cancer and metabolism
The phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and
mammalian target of rapamycin (mTOR) are central regulators of glycolysis, cancer …
mammalian target of rapamycin (mTOR) are central regulators of glycolysis, cancer …
Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases
Class I phosphoinositide 3-kinase (PI3K) generates phosphatidylinositol 3, 4, 5-
trisphosphate (PtdIns (3, 4, 5) P 3) at the plasma membrane in response to growth factors …
trisphosphate (PtdIns (3, 4, 5) P 3) at the plasma membrane in response to growth factors …
Ubiquitin-specific protease 10 determines colorectal cancer outcome by modulating epidermal growth factor signaling via inositol polyphosphate-4-phosphatase type …
K Kubaichuk, T Seitz, U Bergmann, V Glumoff… - Oncogenesis, 2024 - nature.com
Although there have been advances in understanding colorectal cancer (CRC)
pathogenesis, significant gaps still exist, highlighting the need for deeper insights …
pathogenesis, significant gaps still exist, highlighting the need for deeper insights …
Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases
MJ Eramo, CA Mitchell - Biochemical Society Transactions, 2016 - portlandpress.com
The phosphoinositide 3-kinase (PI3K) generated lipid signals, PtdIns (3, 4, 5) P 3 and PtdIns
(3, 4) P 2, are both required for the maximal activation of the serine/threonine kinase proto …
(3, 4) P 2, are both required for the maximal activation of the serine/threonine kinase proto …