Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …

Permutation tests are increasingly being used as a reliable method for inference in
neuroimaging analysis. However, they are computationally intensive. For small, non …

Horses, asses, and zebras belong to a single genus, Equus, which emerged 4.0–4.5 Mya.
Although the equine fossil record represents a textbook example of evolution, the …

Epigenetic changes, including aberrant DNA methylation, result in altered gene expression
and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) …

Motivation Methods for analyzing microbiome data generally fall into one of two groups: tests
of the global hypothesis of any microbiome effect, which do not provide any information on …

Compositional analysis is based on the premise that a relatively small proportion of taxa are
differentially abundant, while the ratios of the relative abundances of the remaining taxa …

DNA replication occurs in a defined temporal order known as the replication-timing (RT)
program. RT is regulated during development in discrete chromosomal units, coordinated …

Motivation Understanding whether and which microbes played a mediating role between an
exposure and a disease outcome are essential for researchers to develop clinical …

Most implementations of mass spectrometry-based proteomics involve enzymatic digestion
of proteins, expanding the analysis to multiple proteolytic peptides for each protein …

An important limitation of standard multiple testing procedures is that the null distribution
should be known. Here, we consider a null distribution-free approach for multiple testing in …