The ability of articular cartilage to repair itself is limited because it lacks blood vessels,
nerves, and lymph tissue. Once damaged, it can lead to joint swelling and pain, accelerating …

Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects
in articular cartilage can induce debilitating degenerative joint diseases such as …

Proteoglycans are vital components of the extracellular matrix in articular cartilage, providing
biomechanical properties crucial for its proper functioning. They are key players in chondral …

This review highlights the multifunctional properties of perlecan (HSPG2) and its potential
roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose …

Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of
tissues and organs, offers great hope for the future of medicine. Cell therapy for treating …

The aim of this study was to highlight the roles of perlecan in the regulation of the
development of the rudiment developmental cartilages and growth plate cartilages, and also …

This review examines the roles of HS–proteoglycans (HS–PGs) in general, and, in
particular, perlecan and syndecan as representative examples and their interactive ligands …

In recent years, as the aging population continues to grow, osteoarthritis (OA) has emerged
as a leading cause of disability, with its incidence rising annually. Current treatments of OA …

Perlecan is a widely distributed, modular, and multifunctional heparan sulfate proteoglycan,
which facilitates cellular communication with the extracellular environment to promote tissue …

As an indispensable component of the extracellular matrix, perlecan (Pln) plays an essential
role in cartilaginous tissue function. Although there exist studies suggesting that Pln …